Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,011-5,020 of 5,253 results
Journal of Neurochemistry, 2025 • February 3, 2025
The study introduces a novel tamoxifen-inducible PDGFRβ+ cell ablation model in mice to investigate pericyte responses in the CNS following acute ablation, addressing limitations in existing models. T...
KEY FINDING: A low dose of tamoxifen effectively ablates PDGFRβ+ cells of the CNS in mice without reducing survival or causing significant systemic side effects, such as weight loss.
Cell Cycle, 2012 • September 1, 2012
The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in multiple cellular functions, such as cell metabolism, proliferation and survival. SCI involves multiple pathophysi...
KEY FINDING: Inhibition of mTOR reduces cell death in damaged neural tissue following SCI.
The American Journal of Human Genetics, 2016 • March 3, 2016
The study identifies loss-of-function mutations in TRIP4 and ASCC1, encoding subunits of the ASC-1 complex, as the cause of a syndrome characterized by prenatal SMA, congenital contractures, respirato...
KEY FINDING: Homozygous and compound heterozygous nonsense and frameshift mutations in TRIP4 and ASCC1 genes cosegregate with a disease phenotype characterized by prenatal-onset SMA and congenital bone fractures.
Neural Regen Res, 2021 • January 1, 2021
Cathepsins are proteases vital for lysosomal function and involved in neuronal plasticity. Their activity must be tightly regulated to prevent detrimental effects. Following spinal cord injury, cathep...
KEY FINDING: Dysregulation of cathepsins, particularly after spinal cord injury, exacerbates inflammation and damages tissue, disrupting processes like autophagy and lysosomal function.
Neural Regeneration Research, 2019 • February 1, 2019
This study investigates the role of MGMT, a DNA repair enzyme, in all-trans retinoic acid (ATRA)-induced spina bifida aperta (SBA) in rats. The study demonstrates that DNA damage occurs in ATRA-induce...
KEY FINDING: DNA damage, indicated by increased γ-H2A.X levels, occurs in ATRA-induced spina bifida aperta (SBA) embryos.
Scientific Reports, 2016 • December 20, 2016
This study investigates the crosstalk between activated microglia and neurons in the spinal dorsal horn and its contribution to stress-induced hyperalgesia using a rat model combining single-prolonged...
KEY FINDING: The study found that stress combined with inflammation (using Complete Freund’s Adjuvant) significantly increased pain sensitivity (mechanical allodynia) in rats.
Eur J Neurol, 2024 • August 4, 2024
This study investigates noncompressive myelopathy as a rare but severe complication of community-acquired bacterial meningitis, identifying seven cases from a nationwide cohort and reviewing 15 additi...
KEY FINDING: Noncompressive myelopathy was reported in 0.23% of community-acquired bacterial meningitis cases.
The Journal of Neuroscience, 2003 • February 15, 2003
This study investigates the role of Rho GTPases and their downstream effectors in axonal regeneration after CNS injury. The researchers found that Nogo-66 directly activates Rho, leading to neurite ou...
KEY FINDING: Nogo-66 directly activates Rho, as demonstrated by increased levels of GTP Rho in PC12 and DRG cell lysates after Nogo-66 stimulation.
Surgical Neurology International, 2025 • January 10, 2025
This paper reports two cases of dural arteriovenous fistulas (DAVFs) of the occipital sinus (OS) that developed after head trauma. These rare vascular malformations pose diagnostic and therapeutic cha...
KEY FINDING: Trauma can be a significant factor in the development of OS DAVFs. Both cases presented involved patients with a history of head trauma prior to the development of the fistula.
Journal of Biomedical Optics, 2011 • October 4, 2011
This study investigates myelin integrity in mice with relapsing experimental autoimmune encephalomyelitis (EAE) using coherent anti-Stokes Raman scattering (CARS) microscopy. The research demonstrates...
KEY FINDING: Paranodal myelin retraction is an early event in relapsing experimental autoimmune encephalomyelitis (EAE), occurring at the onset of the disease and at the borders of acute demyelinating lesions.