Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,061-5,070 of 5,253 results
Front. Aging Neurosci., 2023 • August 2, 2023
This study investigates the role of leukotriene (LT) signaling in cognitive heterogeneity during aging, focusing on the expression of 5-lipoxygenase (5-Lox) and 5-lipoxygenase-activating protein (FLAP...
KEY FINDING: Expression of 5-Lox was increased within the brain of aged rats, with the highest levels detected in cognitively impaired animals, suggesting a link between the LT system and cognitive decline.
The Journal of Spinal Cord Medicine, 2024 • February 28, 2023
This study investigated the neuroprotective effects of PCA on SCI in rats, focusing on the Wnt/β-catenin pathway. The results showed that PCA activated the Wnt/β-catenin signaling pathway, leading to ...
KEY FINDING: PCA treatment activates the Wnt/β-catenin signaling axis in vivo and in vitro.
Neural Plasticity, 2015 • July 2, 2015
This study investigated the potential of combining Schwann cell (SC) transplantation with putrescine supplementation to improve spinal cord injury (SCI) repair in rats. The researchers hypothesized th...
KEY FINDING: Delayed putrescine supplementation significantly increased the size of the SC implant, suggesting enhanced survival or proliferation of the implanted cells.
Journal of Sleep Research, 2024 • January 11, 2024
This case study investigates the use of a rocking bed with vestibular stimulation to improve sleep in a 12-year-old boy with a severe mitochondrial disease and sleep disorder. The study found signific...
KEY FINDING: Sleep duration increased by 25% during the final 4-week intervention period compared to baseline.
Cell Tissue Res, 2018 • January 1, 2018
Neural stem cells (NSCs) are the stem cells of the nervous system. During development they give rise to the entire nervous system. Because NSCs are regulated by both intrinsic genetic and epigenetic p...
KEY FINDING: During development, the central nervous system (CNS) is generated from a small number of neural stem cells (NSCs) lining the neural tube.
JOURNAL OF NEUROTRAUMA, 2015 • November 1, 2015
This study aimed to determine if methylprednisolone improves motor recovery in acute TSCI patients, considering neurological level and injury severity. The results indicated that methylprednisolone di...
KEY FINDING: NASCIS-II methylprednisolone did not improve motor score recovery in RHSCIR patients with acute TSCIs in either the cervical or thoracic spine when the influence of anatomical level and severity of injury were included in the analysis.
Cell Communication and Signaling, 2023 • August 18, 2023
This review discusses the role of the FGF system in axons, providing an original view of this multipurpose family of growth factors in nervous system (dys)function. The FGF family regulates nervous sy...
KEY FINDING: FGF2 promotes axonal elongation and branching in cultured DRGs neurons through activation of FGFR1.
Nature Neuroscience, 2024 • July 1, 2024
This study identifies that stromal fibroblasts forming the fibrotic scar derive from two populations of perivascular cells after spinal cord injury (SCI) in adult mice of both sexes. The contribution ...
KEY FINDING: Stromal fibroblasts forming fibrotic scars after SCI in mice originate from two distinct perivascular cell populations: pericytes and perivascular fibroblasts.
Stem Cell Reports, 2023 • May 9, 2023
The study investigates the behavior of transplanted human retinal organoid cells in photoreceptor-deficient mice. It examines how the recipient retina affects the survival, maturation, and proliferati...
KEY FINDING: Human cells transplanted into mice retinas migrated into all retinal layers, identified as astrocytes and brain/spinal cord-like neural precursors.
Proc. Nad. Acad. Sci. USA, 1986 • October 1, 1986
The study examines the impact of forelimb amputation and denervation on protein synthesis in newt spinal cord ganglia, revealing a significant increase in protein synthesis following amputation. Two-d...
KEY FINDING: Forelimb amputation in newts leads to a fourfold increase in protein synthesis in the brachial nerve ganglia compared to control animals.