Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 111-120 of 144 results
International Journal of Particle Therapy, 2025 • January 1, 2025
This study compares proton SBRT to photon SBRT for spinal metastases, using variable RBE dose models to assess the impact on target coverage and sparing of organs at risk. The results suggest that IMP...
KEY FINDING: Proton therapy (IMPT) significantly improved planning target volume coverage compared to photon therapy (PH-SBRT) at both 30 Gy and 45 Gy doses.
J Vet Res, 2020 • January 1, 2020
This study determined the presence of nitric oxide synthesis isoforms (nNOS, iNOS, and eNOS) in thoracic spinal cord segments and nodose ganglia of rats with gamma-irradiated livers. The nNOS, iNOS, a...
KEY FINDING: nNOS immunoreactivity was found in the superficial lamina (lamina I–II) of the spinal cord of the rats with ionising radiation insult to the liver, and to a lesser extent in lamina III–IV.
Advanced Science, 2023 • November 16, 2022
This study identifies cancer cell lines that are sensitive or resistant to OXPHOS inhibition and reveals that the NNMT-DNMT1 axis plays a critical role in determining cancer cell reliance on mitochond...
KEY FINDING: OXPHOS inhibition-sensitive cancer cells exhibit increased OXPHOS activity and silenced NNMT expression.
J Immunother Cancer, 2021 • January 1, 2021
This study demonstrates the feasibility of redirecting pre-existing viral immunity against measles virus (MeV) to inhibit tumor growth in a preclinical model of aggressive squamous cell carcinoma. The...
KEY FINDING: MeV vaccination generated cytotoxic T lymphocyte (CTL) immunity in mice, demonstrated by enhanced interferon gamma production and antigen-specific T cell proliferation.
Disease Markers, 2022 • May 11, 2022
The study investigates the role of DYNC1H1 in LIHC using bioinformatics and experimental analysis, finding that DYNC1H1 expression is associated with clinicopathological features and poor prognosis. G...
KEY FINDING: DYNC1H1 expression levels were associated with T classification, pathologic stage, histologic grade, and serum AFP levels in LIHC patients.
Cell Communication and Signaling, 2024 • August 6, 2024
This study confirms a myeloproliferative role of NLRP3 by demonstrating that the expression of NLRP3 and the NLRP3 inflammasome-related genes ASC, IL1B, and IL18 is increased in AML patient cells comp...
KEY FINDING: Elevated NLRP3 expression is associated with diminished overall survival in AML patients, suggesting a critical role in AML pathogenesis.
J Neurosurg Case Lessons, 2025 • March 10, 2025
This case report presents a 17-year-old female with spinal osteosarcoma who achieved 20-year disease-free survival following neoadjuvant chemotherapy and en bloc resection, including spinal cord amput...
KEY FINDING: En bloc resection with tumor-free margins, including the spinal cord, can lead to long-term disease-free survival in spinal osteosarcoma, challenging the notion that spinal OS has a universally poor prognosis.
Br. J. Cancer, 1984 • January 1, 1984
The study proposes a model to explain cell survival after multiple radiation doses when complete repair doesn't occur between doses, which transforms into an accumulation model for continuous irradiat...
KEY FINDING: Repair halftimes in mouse tissues (jejunum, colon, bone marrow) ranged from 0.3-0.9 hours, with β/α values around 0.1 Gy-1.
CNS Neuroscience & Therapeutics, 2024 • January 1, 2024
CNS tumors are complex diseases with specific pathogeneses not fully understood and poor prognosis, often resistant to therapies. ncRNAs, including circRNAs, significantly contribute to tumor initiati...
KEY FINDING: CircRNAs participate in multiple molecular mechanisms of cellular normal or pathophysiology processes, especially as miRNA sponges in the cytoplasm, activating the modulation of target genes via miRNA response elements.
Frontiers in Bioengineering and Biotechnology, 2019 • October 15, 2019
This study aimed to identify alternative splicing events (ASEs) associated with prognosis and metastasis in kidney renal clear cell carcinoma (KIRC) using bioinformatic analysis of TCGA data. In this ...
KEY FINDING: Identified 6,081 overall survival-related ASEs (OS-SEs) in KIRC. A total of prognostic 6,081 overall survival-related ASEs (OS-SEs) were identified by univariate Cox regression analysis