Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 181-190 of 555 results
Medicine, 2020 • August 21, 2020
The meta-analysis examined the effect of rTMS and tDCS on neuropathic pain following SCI, using data from multiple studies comparing these treatments to sham stimulations. The study found that rTMS di...
KEY FINDING: rTMS did not show early analgesic effect on NP after SCI compared to sham rTMS.
Neuroscience Insights, 2020 • July 29, 2020
This commentary discusses a study using intravital imaging to observe dendritic spine dynamics in the spinal cord before and after nerve injury-induced pain. The study revealed a time-dependent relati...
KEY FINDING: The study revealed a time-dependent relationship between the increase in pain and changes in dendritic spine structure after nerve injury.
Neurorehabilitation and Neural Repair, 2020 • November 1, 2020
This longitudinal study investigated the evolution of conditioned pain modulation (CPM) over time in patients with spinal cord injury (SCI) and explored its relationship with clinical pain. The study ...
KEY FINDING: A significant decrease in the efficacy of conditioned pain modulation (CPM) was observed over time in patients with SCI.
Molecular Pain, 2020 • January 1, 2020
The study investigates the effects of different spinal cord stimulation (SCS) techniques on cell-specific transcriptomes in a rat model of neuropathic pain. It compares differential target multiplexed...
KEY FINDING: DTMP yielded strong and significant correlations to expression levels found in the healthy animals across every evaluated cell-specific transcriptome.
Top Spinal Cord Inj Rehabil, 2020 • July 1, 2020
The article highlights the importance of primary care providers (PCPs) in managing chronic pain among individuals with spinal cord injury (SCI). It emphasizes the need for PCPs to recognize different ...
KEY FINDING: Chronic pain is highly prevalent among individuals with SCI, significantly affecting their quality of life.
Spinal Cord Series and Cases, 2020 • September 21, 2020
This case report details the effects of spinal cord stimulation (SCS) and rehabilitation on a 48-year-old male with chronic complete L1 paraplegia due to a conus medullaris injury. The patient underwe...
KEY FINDING: Motor ZPPs advanced from L1 to L5 on the left and from L1 to L3 on the right after 18 months of SCS and physical therapy.
Spinal Cord Series and Cases, 2020 • October 17, 2020
This study investigates the effects of transcranial direct current stimulation (tDCS) on motor cortex excitability (MCE) and pain intensity in individuals with chronic spinal cord injury neuropathic p...
KEY FINDING: Four individuals showed a negative variation of motor cortex excitability (MCE) after tDCS, with two reporting a reduction in pain intensity.
Scientific Reports, 2020 • November 27, 2020
The study compared conventional tonic SCS to four dynamically modulated SCS (TDPs) in a rat model of neuropathic pain, using sub-perception thresholds. Results showed that all SCS patterns except puls...
KEY FINDING: All tested SCS patterns except pulse width modulation significantly reversed mechanical hypersensitivity in rats.
AGING, 2021 • December 3, 2020
The study identified a novel role for DOK3 protein in activated microglia-induced neuropathic pain. It induced immune responses and neuropathic pain by a physical interaction with GPR84. Knockdown of...
KEY FINDING: Knockdown of DOK3 in microglial cells dramatically reduced the levels of inflammatory factors, suggesting that DOK3 regulates the release of a subset of inflammatory mediators in microglia under physiologic conditions.
Neurospine, 2020 • December 1, 2020
This review summarizes recommendations from the WFNS Spine Committee on SCI rehabilitation, covering physiotherapy, FES, and surgical pain management. Physiotherapy includes various techniques to rest...
KEY FINDING: Various physiotherapeutic treatments like massage, cryotherapy, laser therapy, and exercise therapy can aid in restoring musculoskeletal function and reducing spasticity.