Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 191-200 of 555 results
Ann Rehabil Med, 2020 • December 31, 2020
This study investigated the prevalence and characteristics of neuropathic pain (NP) in spinal cord injury (SCI) patients using the International Spinal Cord Injury Pain (ISCIP) classification. The stu...
KEY FINDING: The prevalence of NP in patients with SCI was 69.1% according to the ISCIP classification.
PAIN Reports®, 2020 • September 23, 2020
This review explores the mechanisms of exercise-induced analgesia in animal models, focusing on both pain prevention and alleviation. It addresses questions about the appropriate prescription of exerc...
KEY FINDING: Exercise-induced analgesia is mediated by endogenous opioid activity, as studies show that naloxone, an opioid receptor antagonist, blocks the analgesic effects of exercise.
Medicine, 2021 • February 1, 2021
This paper presents two case reports where burst spinal cord stimulation (b-SCS) was used to treat patients with central neuropathic pain resulting from spinal cord injury (SCI) or traumatic brain inj...
KEY FINDING: Burst SCS was effective in reducing pain intensity and frequency in a patient with neuropathic pain following spinal cord injury.
Spinal Cord, 2021 • February 16, 2021
This study assessed the reliability of standardized quantitative pain drawings in patients with neuropathic pain (NP) following spinal cord injury (SCI). The average extent [%] and intensity [NRS 0–10...
KEY FINDING: Pain extent showed excellent inter-session reliability (intraclass correlation coefficient 0.96).
Molecular Pain, 2021 • February 9, 2021
This study explores the impact of different spinal cord stimulation (SCS) parameters on microglial activation in a rat model of neuropathic pain. The researchers compared differential target multiplex...
KEY FINDING: DTMP shows the highest significant correlations to expression levels found in healthy animals across all microglial activation transcriptomes, indicating a modulation towards a healthy state.
Neural Plasticity, 2021 • February 20, 2021
This bibliometric study analyzes research trends on pain after spinal cord injury (SCI) from 1990 to 2019. It uses data from the Web of Science Core Collection and CiteSpace software to identify key c...
KEY FINDING: The number of publications on pain after SCI increased significantly from 1990 to 2019, indicating growing research interest in this area.
Front. Mol. Neurosci., 2021 • February 25, 2021
The study demonstrates that NL1 expression is upregulated in excitatory neurons of the spinal dorsal horn in a mouse model of neuropathic pain (SNI). Reducing NL1 levels in excitatory neurons through ...
KEY FINDING: NL1 is upregulated in the L4–L6 spinal dorsal horn in Vglut2-cre+/−mouse subjected to spared nerve injury (SNI).
Stem Cell Research & Therapy, 2021 • January 31, 2021
This study demonstrates that NCSCs delivered at the injury site using a scaffold ameliorate neuropathic pain and enhance locomotion after PNI through inhibiting glial activation as well as ERK and NF-...
KEY FINDING: NCSC-laden nerve scaffolds mitigated SNT-induced neuropathic pain and improved motor function recovery after sciatic nerve repair.
Journal of International Medical Research, 2021 • March 1, 2021
This case report describes successful outcomes in two patients with refractory upper limb pain after spinal cord injury and upper limb amputation using burst waveform SCS. Conventional tonic waveform ...
KEY FINDING: Conventional tonic waveform SCS was not very effective for pain reduction in either patient with refractory upper limb pain.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
A traumatic injury to the spinal cord causes an immediate cascade of inflammatory responses that, among other things, can initiate hypersensitivity within nociceptive pathways leading to chronic neuro...
KEY FINDING: Higher BMI is associated with greater pain severity in persons with chronic SCI, irrespective of the type of pain.