Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 171-180 of 555 results
Molecular Pain, 2020 • April 3, 2020
The study investigates the effect of exercise training on neuropathic pain (NPP) after spinal cord injury (SCI) in rats, focusing on the role of glutamic acid decarboxylase (GAD) and tropomyosin-relat...
KEY FINDING: Spinal cord injury leads to mechanical allodynia and thermal hyperalgesia and altered BDNF expression in rats.
Clinical and Translational Gastroenterology, 2020 • February 7, 2020
This prospective, single-arm study was designed to evaluate the safety and efficacy of 10-kHz spinal cord stimulation (SCS) in patients with intractable CAP over a 12-month follow-up period. After 12 ...
KEY FINDING: After 12 months of treatment with 10-kHz SCS, 78.3% of subjects were responders (pain relief of ‡50%).
AGING, 2020 • June 9, 2020
This study investigates the role of Mlxipl in neuropathic pain (NP), focusing on its impact on neuroinflammation in the spinal dorsal horn (SDH) following peripheral nerve injury. The key findings dem...
KEY FINDING: Mlxipl expression is upregulated in the ipsilateral spinal dorsal horn (SDH) of rats with Spared Nerve Injury (SNI)-induced mechanical allodynia.
Pain Practice, 2020 • January 1, 2020
This prospective, multicenter study evaluated the effectiveness of 10-kHz SCS for chronic postsurgical pain (CPSP). The study demonstrated significant pain reduction, improved patient function, and en...
KEY FINDING: The mean VAS score decreased by 6.5 cm after 12 months of treatment, indicating a substantial reduction in pain intensity.
J Trauma Acute Care Surg, 2020 • October 1, 2020
This study investigated pain intensity and interference in individuals with burn, TBI, and SCI compared to the general population, using a custom PROMIS pain interference short form. The results showe...
KEY FINDING: At the start of the study, individuals in all three injury groups (burn, TBI, and SCI) reported significantly higher pain intensity and interference compared to the general population.
Neurology, 2020 • August 18, 2020
This study investigated the relationship between neuroinflammatory and neurodegenerative metabolites in the cervical spinal cord and neuropathic pain (NP) in patients with spinal cord injury (SCI). Th...
KEY FINDING: Patients with neuropathic pain (NP) showed increased levels of tCho/mI compared to pain-free patients after spinal cord injury (SCI).
Heliyon, 2020 • July 16, 2020
This paper presents a case report of a patient with spinal cord injury (SCI) at-level pain who was successfully treated with peripheral subcutaneous field stimulation (PSFS) and a literature review of...
KEY FINDING: A patient with SCI at-level pain experienced near complete pain relief with PSFS and ceased all narcotic use for pain management.
PAIN Reports, 2020 • July 20, 2020
This pilot study investigated the feasibility and safety of conditioning open-label placebo (COLP) as a pharmacobehavioral intervention to decrease opioid consumption in patients with pain in comprehe...
KEY FINDING: Conditioning open-label placebo significantly reduced total opioid consumption by the end of the intervention period.
Neuromodulation, 2021 • January 1, 2021
The study evaluated the effects of conventional and high-frequency spinal cord stimulation (SCS) on below-level mechanical hypersensitivity in rats with spinal cord injury (SCI). Both SCS paradigms mo...
KEY FINDING: Both conventional SCS (50 Hz, 80% MoT) and high-frequency SCS (1200 Hz, 40% MoT) attenuated hind paw mechanical hypersensitivity in SCI rats.
J Neurol Neurosurg Psychiatry, 2020 • August 11, 2020
This retrospective longitudinal study explored the association between spared spinal cord tissue and neuropathic pain (NP) development after spinal cord injury (SCI). The study found that patients wit...
KEY FINDING: Patients with neuropathic pain had larger ventral tissue bridges at 1 month compared to pain-free patients.