Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 201-210 of 555 results
Frontiers in Neuroscience, 2021 • March 22, 2021
This study investigates the effects of combining environmental enrichment (EE) and ketamine on neuropathic pain and motor dysfunction in rats with spinal cord injury (SCI). The results demonstrate tha...
KEY FINDING: The joint treatment of EE and ketamine provided greater relief of pain-like behaviors and locomotor recovery than either paradigm alone.
Molecular Pain, 2021 • March 9, 2021
The study examined whole blood gene expression in individuals with chronic SCI compared to able-bodied individuals, focusing on differences based on pain status and pain type. Results showed distinct ...
KEY FINDING: Participants with SCI who reported pain had 468 differentially expressed (DE) genes compared to able-bodied (AB) individuals, while those without pain had 564 DE genes.
JOURNAL OF REHABILITATION MEDICINE, 2020 • August 31, 2020
This study shows that patients with a cervical or thoracic SCI concurrent with signs of damage to LSCR have a lower prevalence of spasticity. As expected, no such association was found for BLSCIN pain...
KEY FINDING: Among 161 patients without damage to the lumbar spinal cord and roots, 87% of those with cervical spinal cord injury experienced spasticity, compared with 85% with thoracic spinal cord injury.
J Neural Eng, 2022 • January 1, 2022
This study investigates the potential of motor-targeted intraspinal microstimulation (ISMS) to simultaneously modulate spinal nociceptive transmission. The researchers characterized the neuromodulator...
KEY FINDING: Sub-motor threshold ISMS delivered to spinal motor pools immediately modulates concurrent nociceptive transmission
Spinal Cord Series and Cases, 2022 • September 30, 2022
This case report describes a rare instance of spinal cord compression caused by a spinal cord stimulator (SCS) electrode array in a 58-year-old woman with a history of back pain and multiple spine sur...
KEY FINDING: The case report highlights a very rare complication of SCS, spinal cord compression due to the electrode array.
Mediators of Inflammation, 2022 • September 30, 2022
The study investigates the effects of LPA on spinal cord neurons, particularly concerning cytotoxicity, apoptosis, DNA damage, and oxidative stress, using an in vitro model. It finds that LPA (18:1) n...
KEY FINDING: LPA (18:1) treatment decreases cell viability and increases LDH release in spinal cord neurons, indicating cytotoxicity.
Journal of Neuroinflammation, 2022 • November 8, 2022
The study investigated the connection between neuropathic pain (NP) and neuroinflammation (NIF) following spinal cord injury (SCI) in rats. The researchers explored whether NP coexists with changes in...
KEY FINDING: SCI resulted in impaired sensorimotor functions, altered reflexes, and hypersensitivity to painful stimuli.
Top Spinal Cord Inj Rehabil, 2022 • October 1, 2022
This phase I randomized controlled trial will investigate the effectiveness of cognitive multisensory rehabilitation (CMR) for neuropathic pain relief in adults with spinal cord injury (SCI). The stud...
KEY FINDING: The study aims to determine baseline differences in brain function between adults with SCI and uninjured controls using fMRI.
Dtsch Arztebl Int, 2022 • December 2, 2022
Complex regional pain syndrome (CRPS) is a relatively common complication, occurring in 5% of cases after injury or surgery, particularly in the limbs. The incidence of CPRS is around 5–26/100 000. Re...
KEY FINDING: CRPS is now categorized as a primary pain condition of multifactorial origin under the ICD-11.
Neurology® 2023 • March 14, 2023
This phase 3 study evaluated the efficacy and safety of mirogabalin for treating central neuropathic pain (CNeP) in Asian patients with spinal cord injury (SCI). The study found that mirogabalin signi...
KEY FINDING: Mirogabalin significantly improved pain compared to placebo, as measured by the weekly average daily pain score (ADPS) at week 14.