Pain Management Research

KEY FINDING: Standard pain management, largely pharmacological, is often ineffective in providing significant or lasting relief for chronic pain in TSCI patients.

KEY FINDING: For five out of the six participants, a majority of outcomes improved during either of the intervention phases or both.

KEY FINDING: NKCC1 protein expression was significantly upregulated in the spinal cord and DRGs of rats with SCI.

KEY FINDING: Current evidence supports the use of 10 Hz HF-rTMS of the primary motor cortex to reduce neuropathic pain.

KEY FINDING: Intrathecal administration of Resveratrol (Res) alleviated mechanical allodynia in rats with spinal cord injury (SCI) for up to 21 days.

KEY FINDING: The literature review identified seven studies (five case reports and two case series) that evaluated topical analgesics for SCI-related NP, with all reporting a decrease in NP over time.

KEY FINDING: SCI induces ectopic expression of Nav1.7 in SDH neurons, making them hypersensitive and contributing to central sensitization and spontaneous/walking-evoked mechanical pain.

KEY FINDING: High-frequency spinal cord stimulation (HF-SCS) and burst spinal cord stimulation (B-SCS) have been shown to have the most promising effect in improving pain intensity and frequency.

KEY FINDING: Downregulation of neuronal membrane KCC2 (mKCC2) in the spinal dorsal horn of SNI mice is closely associated with SNI-induced dynamic allodynia.

KEY FINDING: Higher neuropathic pain severity was significantly associated with lower connectivity between the right posterior parahippocampal gyrus (pPaHC) to the right putamen and amygdala.