Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 361-370 of 555 results
Frontiers in Neurology, 2019 • August 27, 2019
The study aimed to clarify the impact of prior pain episodes on motor learning in intact rats. Rats were trained to cross a horizontal ladder, subjected to pain episodes using inflammatory agents (cap...
KEY FINDING: Prior pain episodes induced by capsaicin and CFA negatively affected motor learning in neurologically intact rats, as indicated by slower adaptation to the novel ladder pattern.
Pain Research and Management, 2019 • April 28, 2019
The study aimed to clarify the mechanisms underlying pain reduction by PRF treatment on DRG, focusing on the levels of BDNF, PI3K, and p-ERK in the spinal cord of rats with spared nerve injury (SNI). ...
KEY FINDING: SNI induced a long-lasting increase in microglia hyperactivity and BDNF, PI3K, and p-ERK upregulation in the spinal cord and resulted in pain sensitization.
Spinal Cord Series and Cases, 2019 • March 17, 2019
This study used International SCI Data Sets to assess pain and quality of life (QoL) in adults with chronic SCI. The study found a high prevalence of complex and persistent pain symptoms in individual...
KEY FINDING: Most participants with SCI reported having multiple types and locations of pain, despite receiving treatment for pain.
GMS German Medical Science, 2019 • June 17, 2019
This clinical practice guideline provides a structured approach to pain management in individuals with spinal cord injury (SCI), addressing challenges in classification, assessment, and therapy. The g...
KEY FINDING: The guideline recommends the International Spinal Cord Injury Pain (ISCIP) classification for SCI-related pain.
BMC Neuroscience, 2019 • July 23, 2019
This study investigated whether post-surgical inhibition of PI3K could alleviate postoperative pain (POP) and the underlying mechanisms in mice subjected to plantar incision. The results demonstrated ...
KEY FINDING: Post-surgical inhibition of PI3K significantly reduced mechanical allodynia, thermal hyperalgesia, and cumulative pain scores in male mice after plantar incision.
Frontiers in Neuroscience, 2019 • July 25, 2019
This study investigated the feasibility of self-managed neurofeedback (NFB) treatment for central neuropathic pain (CNP) in individuals with chronic spinal cord injury (SCI). The results showed that a...
KEY FINDING: Twelve participants achieved statistically significant reduction in pain, and in eight participants this reduction was clinically significant (larger than 30%).
Spine Surg Relat Res, 2019 • January 1, 2019
This nationwide survey investigated spinal cord-related pain syndrome in Japan, focusing on neuropathic pain associated with spinal cord damage. The study identified common underlying conditions, the ...
KEY FINDING: The most frequent underlying conditions were cervical spondylotic myelopathy (26.7%), spinal cord injury (17.4%), and ossification of the posterior longitudinal ligament (OPLL) of the cervical spine (14.1%).
ANNALS OF NEUROSCIENCES, 2019 • April 1, 2019
This review aims to discuss the implications of various mechanistic approaches of yoga which can be tested by new study designs around various nociceptive molecules including matrix metalloproteinases...
KEY FINDING: Yoga may increase pain tolerance in SCI and other patients with pain. Various studies have noted improvement in sleep, mood, and quality of life (i.e. depression, emotional function, anxiety) among cancer patients.
CANADIAN JOURNAL OF PAIN/REVUE CANADIENNE DE LA DOULEUR, 2017 • January 1, 2017
A national Canadian summit was held to develop a strategic plan for improving neuropathic pain (NP) management after spinal cord injury (SCI). The summit identified strengths, such as evidence synthes...
KEY FINDING: Strengths in the field include rigorous evidence syntheses and practice landscape documentation, such as the CanPainSCI Clinical Practice Guidelines and the SCIRE website.
Frontiers in Physiology, 2012 • October 4, 2012
The experiments were designed to test for cross-talk between spinal training and nociceptive plasticity in complete SCI. The results indicate that spinal training history can influence future nocicepti...
KEY FINDING: Spinal training history influences future nociceptive responsiveness to formalin. Specifically, uncontrollable stimulation enhances tactile hyper-reactivity.