Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 421-430 of 555 results
Neural Regeneration Research, 2016 • December 1, 2016
This study examines the impact of "Three Methods and Three Points" tuina therapy on rats with sciatic nerve injuries, focusing on pain reduction, muscle recovery, and nerve regeneration. The findings ...
KEY FINDING: Tuina treatment improved paw withdrawal latency, indicating reduced pain sensitivity in the treated rats.
Molecular Pain, 2017 • January 1, 2017
The study investigates the role of Shank2 protein in NMDA-induced pain hypersensitivity in mice, focusing on the spinal cord mechanisms involved. It demonstrates that Shank2 knockout mice exhibit redu...
KEY FINDING: Intrathecal NMDA injection evoked spontaneous nociceptive behaviors, which were significantly reduced in Shank2 KO mice, suggesting that the spinal Shank2 protein is involved in NMDA-induced pain transmission.
Cell Transplantation, 2017 • March 23, 2017
The study examines the impact of OEC/ONF transplants on forepaw thermal responses following dorsal root avulsion in rats, finding that transplants prevented heightened sensitivity to heat and cold. Hi...
KEY FINDING: Dorsal root avulsion in rats leads to a transient period of exaggerated responses to heat and cold stimuli on the forepaw.
Scientific Reports, 2017 • August 17, 2017
This study investigates the therapeutic potential of human anti-RGMa antibodies in treating spinal cord injury (SCI) by promoting regeneration and reducing neuropathic pain. The research demonstrates ...
KEY FINDING: RGMa is significantly upregulated in multiple cell types following impact-compression SCI in rats and in the injured human spinal cord.
Data in Brief, 2017 • October 7, 2017
This data article presents findings on the expression patterns of leptin (Lep) and its receptor (LepR) in the dorsal root ganglion (DRG) and spinal cord following preganglionic cervical root avulsion ...
KEY FINDING: Generalized expression of Lep and LepR was noted 7 days after PCRA in DRG neurons.
Frontiers in Pharmacology, 2017 • October 17, 2017
This work demonstrates the effect of combined long-chain omega-3 fatty acids (CFO), EPA and DHA, in nerve regeneration and prevention of NP in mice, shedding light on its mechanism of action. Our resul...
KEY FINDING: CFO at 2.3 g/kg significantly prevented mechanical allodynia and reduced thermal hypernociception in mice compared to animals receiving vehicle only.
Toxins, 2018 • March 18, 2018
This study aimed to verify if BoNT/B is able to counteract neuropathic pain, and to interfere with inflammatory and regenerative processes associated with nerve injury. The results of this study show ...
KEY FINDING: BoNT/B reduces neuropathic pain over a long period of time, similar to BoNT/A.
Molecular Pain, 2018 • April 10, 2018
This study investigated the effects of blocking TRPV1 with AMG-517 on nerve regeneration after sciatic nerve injury in rats. The results showed that AMG-517 promoted axonal regeneration, decreased gli...
KEY FINDING: Blockage of TRPV1 with AMG-517 markedly promoted axonal regeneration, especially at two weeks after sciatic injury.
Medical Devices: Evidence and Research, 2018 • January 1, 2018
The study introduces a novel electroceutical device that delivers percutaneous direct current (DC) stimulation to treat severe neurological pain and soft tissue injuries. The device mimics and modulat...
KEY FINDING: Percutaneous DC stimulation significantly reduced pain and attack frequency in a patient with chronic cluster headaches, leading to complete remission for over 3 years.
PNAS, 2018 • August 20, 2018
The study reveals that advillin, a sensory neuron-specific protein, plays a critical role in axonal regeneration of IB4+ sensory neurons and facilitates recovery from peripheral neuropathy and neuropa...
KEY FINDING: Advillin expression is restricted to isolectin B4-positive (IB4+) neurons in the adult dorsal root ganglia (DRG).