Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 411-420 of 555 results
eLife, 2024 • November 15, 2024
This study demonstrates that resident astrocytes, rather than ependymal cells, are the main contributors to neuropathic pain following spinal cord injury (SCI). Selective elimination of resident astro...
KEY FINDING: Resident astrocytes, not ependymal cells, are the primary source of astrocytes that induce neuropathic pain after SCI.
European Journal of Pain, 2025 • January 1, 2025
This translational study examined the interaction between descending inhibitory controls and spinal amplification in pain modulation, using parallel human and rat models. The study found that spinal a...
KEY FINDING: In humans, concurrent application of a noxious conditioning stimulus did not affect pain ratings to a single pinprick stimulus, repetitive stimulation or the wind-up ratio.
Frontiers in Neuroscience, 2025 • January 17, 2025
The study investigates the impact of epidural ULF neuromodulation on thalamic neuron responses to peripheral sensory stimulation and pathological thalamic activity in a neuropathic pain model. Results...
KEY FINDING: ULF current can acutely and reversibly interrupt signaling between sensory afferent fibers and relay neurons of the thalamus.
Front. Neuroanat., 2015 • April 10, 2015
This study investigates the impact of pelvic and hypogastric nerve injuries on the central terminals of sensory axons in the sacral and upper lumbar spinal cord of rats. The researchers examined chang...
KEY FINDING: Pelvic nerve injury increased GFRα1-immunoreactivity (IR) in the medial dorsal horn of the sacral spinal cord.
Exp Neurol, 2015 • September 1, 2015
This study investigated the effects of artemin, NGF, and GDNF on sensory axon regeneration following dorsal root injury in rats, focusing on the extent and topographic targeting of regenerating axon s...
KEY FINDING: Artemin, when expressed in the spinal cord, selectively induced regeneration of CGRP+ axons (related to pain sensation) and promoted their topographic targeting within the superficial dorsal horn.
Neural Regeneration Research, 2015 • October 1, 2015
This study investigates the expression profiles of aminoacyl-tRNA synthetases (AminoARSs) in the spinal cord dorsal horn following peripheral nerve injury in rats. The results demonstrate that the mRN...
KEY FINDING: Following sciatic nerve axotomy in rats, the mRNA expression of FARSB, IARS, and MARS significantly increased in the injured L4–5 spinal cord compared to control regions.
PLoS ONE, 2016 • April 6, 2016
This study identifies and characterizes two potent and selective arylsulfonamide Nav1.7 inhibitors, PF-05198007 and PF-05089771, to investigate Nav1.7's role in nociceptor physiology. The findings dem...
KEY FINDING: Nav1.7 is the predominant functional TTX-sensitive Nav in mouse and human nociceptors, contributing to the initiation and upstroke phase of the nociceptor action potential.
PLoS ONE, 2016 • July 21, 2016
This study investigates the potential of human amniotic fluid-derived mesenchymal stem cells (hAFMSCs) to alleviate neuropathic pain in a rat model of chronic constriction injury (CCI). The results de...
KEY FINDING: hAFMSCs attenuated the expression IL-1β, TNF-α and synaptophysin in dorsal root ganglion cell culture.
The Journal of Neuroscience, 2016 • November 16, 2016
This study examined the synaptic integration of transplanted medial ganglionic eminence (MGE) cells into the adult spinal cord. The researchers found that MGE cells integrate into host circuitry, deve...
KEY FINDING: MGE cells transplanted into the spinal cord, whether before or after nerve injury, develop into mature neurons with firing patterns characteristic of inhibitory interneurons.
Redox Biology, 2017 • January 1, 2017
This study investigates the role of PKG1 in neuropathic pain and nerve regeneration. The research demonstrates that PKG1 deficiency impairs nerve regeneration, leading to increased neuropathic hyperal...
KEY FINDING: PKG1 deficiency in peripheral neurons exacerbates neuropathic pain and impairs nerve regeneration after injury.