Pain Management Research

KEY FINDING: The Randall-Selitto test effectively detected neuropathic pain in both forepaws and hindpaws of rats with spinal cord injuries, regardless of whether the injury was a contusion or a complete transection.

KEY FINDING: Nav1.7 is robustly expressed in small diameter DRG neurons, particularly in both peptidergic and non-peptidergic subpopulations.

KEY FINDING: Artemin transiently reversed tactile and thermal hypersensitivity following axotomy, ligation or crush injury.

KEY FINDING: NGF-induced sprouting of CGRP axons in normal animals resulted in a significant redistribution of synapses and cFos expression into the deeper dorsal horn, leading to severe chronic pain.

KEY FINDING: Incision surgery decreased the withdrawal threshold of rats at 0.5, 3, 6 and 24 hours after incision, compared with the sham surgery group.

KEY FINDING: Intrathecal bumetanide could decrease cumulative pain scores, and could increase thermal and mechanical pain thresholds in a rat model of incisional pain.

KEY FINDING: Suspended moxibustion at Tianshu (ST25) significantly decreased visceral sensitivity to colorectal distention in rats with CVH.

KEY FINDING: CRPS can be classified into two main categories: type 1 and type 2, with type 2 resulting from nerve damage.

KEY FINDING: Oligodendrocyte loss or dysfunction contributes to neuropathic pain following peripheral nerve injury, spinal cord injury, chemotherapy, and HIV infection.

KEY FINDING: Pharmacological activation of spinal mTORC2 induces pain hypersensitivity.