Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 461-470 of 555 results
Neural Regeneration Research, 2025 • November 1, 2025
This study investigates the sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury. The research found that tamoxifen, a selective estrogen rece...
KEY FINDING: Tamoxifen treatment decreased allodynia only in female rats with spinal cord injury, revealing a sex-dependent effect.
IBRO Neuroscience Reports, 2024 • September 5, 2024
The study aimed to explore the potential therapeutic effects of irisin on chronic neuralgia and related affective disorders in a CCI mice model. The results indicated that irisin treatment could allev...
KEY FINDING: Irisin treatment ameliorated CCI-induced mechanical allodynia, thermal hyperalgesia, depressive, and anxiety behaviors in mice.
PAIN Reports, 2024 • November 6, 2024
This study investigates the role of spinal HDACs in chronic constriction injury (CCI)-induced neuropathic pain in rats, focusing on the GABA system. The results demonstrate that CCI upregulates HDAC3,...
KEY FINDING: Spinal hdac3, hdac4, and hdac6 were upregulated in CCI rats, indicating their potential role in neuropathic pain.
J Clin Invest, 2025 • December 10, 2024
The study identifies C2230 as a state- and use-dependent CaV2.2 channel blocker, meaning it preferentially inhibits channels that are frequently activated or in an inactivated state. C2230 was shown t...
KEY FINDING: C2230 inhibits CaV2.2 channels in rat, marmoset, and human neurons in a G-protein-coupled-receptor–independent manner.
Frontiers in Immunology, 2024 • December 6, 2024
This scoping review characterizes the changes in spinal microglia over time in murine models of chronic pain. This study also evaluates the importance of the time points that different studies used to...
KEY FINDING: Most studies used inbred, young adult, male mice with peripheral nerve injury, limiting the generalizability of the data.
Neurosurgical Review, 2025 • January 1, 2025
This study compares the surgical outcomes of DREZL between patients with SCI and those with CEI to investigate predictors of favorable operative outcomes. The CEI group demonstrated significant pain i...
KEY FINDING: Patients with CEI had significantly better long-term pain reduction after DREZotomy compared to those with SCI.
CNS Neuroscience & Therapeutics, 2025 • January 1, 2025
The study aimed to understand how NDSM, known for analgesic efficacy, works to relieve pain, focusing on GABAA receptors and neuroinflammation. The results indicate that NDSM's analgesic effects are p...
KEY FINDING: NDSM demonstrates significant analgesic effects against chronic pain in both pain-evoked and pain-suppressed behavioral assays.
eNeuro, 2025 • January 1, 2025
The study investigated TrkB signaling in DRG neurons as a potential neural mechanism that underlies pain hypersensitivity after SCI. The results revealed that TrkB-mediated inward current and its prot...
KEY FINDING: SCI decreased 7,8-DHF-induced current while increasing the latency to its peak amplitude.
Frontiers in Neuroanatomy, 2025 • January 7, 2025
This review discusses the limitations of current neuropathic pain treatments and introduces a novel approach using capsaicin and RTX. Preclinical data suggests that applying these substances to uninju...
KEY FINDING: In an animal model of neuropathic pain, application of capsaicin or RTX to adjacent uninjured nerves completely alleviated and prevented mechanical and thermal hyperalgesia following L5 nerve injury.
Cureus, 2024 • December 24, 2024
Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by significant sensory, motor, and autonomic dysfunction, often following trauma or nerve injury. The management of CRPS...
KEY FINDING: CRPS involves a complex interplay of peripheral and central mechanisms, neurogenic and classic inflammation, and potential autoimmune and psychological influences.