Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 471-480 of 555 results
J. Clin. Med., 2025 • January 20, 2025
The aim of this study was to evaluate the effects of spinal cord stimulation (SCS) on pain, neuropathic symptoms, and other health-related metrics in patients with chronic painful peripheral neuropath...
KEY FINDING: SCS produced a significant consistent and sustained improvement in pain intensity by 49% in DN4 and 76% in VAS.
Journal of Pain Research, 2025 • January 21, 2025
The study comprehensively analyzed methodology and technical challenges and pitfalls encountered during the development and implementation of this model. We presented a reliable electrophysiological p...
KEY FINDING: SNI enhanced the C component of eLFPs in bilateral cortexes elicited by stimulating the contralateral but not the ipsilateral lateral aspect of the hind paw.
Cureus, 2024 • December 29, 2024
This case report presents a rare instance of bilateral foot drop following cervical decompression in a patient with tandem spinal stenosis, complicated by white cord syndrome. The patient's postoperat...
KEY FINDING: The patient experienced transient improvements post-cervical decompression but later developed delirium, worsening right-sided weakness, and bilateral foot drop.
bioRxiv, 2025 • February 25, 2025
This study challenges the traditional understanding of noradrenergic modulation of spinal nociceptive transmission by demonstrating that targeted blockade of spinal α2 receptors can promote anti-nocic...
KEY FINDING: Targeted blockade of spinal α2 adrenoceptors can reduce spinal nociceptive transmission in vivo.
Frontiers in Neurology, 2025 • February 7, 2025
This study employs bibliometric analysis to explore trends and emerging hotspots in research on the relationship between glial cells and neuropathic pain. Based on literature data from the Web of Scie...
KEY FINDING: China and the United States are the leading countries in research on glial cells and neuropathic pain, with the University of California system being the top institution.
Turk J Phys Med Rehab, 2024 • December 19, 2023
This case report describes a 42-year-old female with persistent neuropathic pain in her soles following a cervical spinal cord injury. The patient had been experiencing this pain for eight years and h...
KEY FINDING: Daytime and nighttime pain levels (Visual Analog Scale) improved after botulinum toxin type A injection.
Journal of Pain Research, 2025 • March 7, 2025
This study investigates the therapeutic effects of electroacupuncture (EA) on neuropathic pain (NP) in a rat model. The research focuses on the role of NLRP3 inflammasome-mediated pyroptosis in microg...
KEY FINDING: EA treatment significantly alleviated pain hypersensitivity by increasing the MWT and PWL in CCI rats.
Bioelectronic Medicine, 2025 • March 6, 2025
The study investigated the effects of low-intensity trans-spinal focused ultrasound (tsFUS) on neuropathic pain in rats with chronic constriction injury (CCI). tsFUS was applied to the L5 spinal segme...
KEY FINDING: tsFUS treatment increased the von Frey threshold (vFT) in rats with CCI compared to sham treatment, indicating reduced mechanical sensitivity. This effect persisted for up to 23 days post-CCI.
The Journal of Neuroscience, 1996 • August 15, 1996
This study demonstrates that topical capsaicin treatment to the sciatic nerve results in novel transganglionic B-HRP staining in lamina II, suggesting that uninjured A-fiber central terminals can coll...
KEY FINDING: Topical capsaicin treatment to the sciatic nerve results in novel transganglionic B-HRP staining in lamina II.
NEUROGENESIS, 2016 • November 1, 2016
Adult spinal cord neurogenesis is a process where new neurons are generated in the spinal cord, influencing pain sensitivity. Under normal conditions, it helps maintain a stable level of pain sensitiv...
KEY FINDING: Adult spinal cord neurogenesis contributes to maintaining a steady-state level of nociceptive sensitivity under normal conditions.