Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 481-490 of 555 results
J Spinal Cord Med, 2005 • January 10, 2005
This case series explores the use of interventional spine therapy in managing chronic pain in patients with spinal cord injury (SCI). The interventions, such as epidural injections, helped identify pa...
KEY FINDING: Interventional spine therapy was useful in identifying the source of pain in SCI patients with neuropathic pain.
J Spinal Cord Med, 2005 • July 13, 2005
This study examined the prevalence of visceral pain and its relationship to quality of life in individuals with spinal cord injury (SCI) at 5, 10, and 15 years post-injury. The study found that the pr...
KEY FINDING: The rates of visceral pain increased at each measurement (10% at year 5, 22% at year 10, and 32% at year 15).
MOLECULAR MEDICINE REPORTS, 2017 • January 1, 2017
The study aimed to investigate gene alterations in patients with spinal cord injury (SCI) and to further examine the mechanisms underlying neuropathic pain (NP) following SCI. A total of 70 upregulate...
KEY FINDING: A total of 70 upregulated and 61 downregulated DEGs were identified in the PBMC samples from patients with NP.
Spinal Cord Series and Cases, 2018 • May 26, 2018
Cannabis presents a complex challenge due to its intricate effects on the central nervous system. Practitioners hold differing opinions on cannabis, awaiting more definitive evidence regarding its the...
KEY FINDING: The composition of cannabis sativa is complex, consisting of hundreds of cannabinoids as well as terpenes, flavinoids, and phenoids.
Int. J. Mol. Sci., 2025 • March 13, 2025
This study aimed to elucidate the molecular mechanisms underlying the combined use of LGZ and SIN in treating NP using network pharmacology and metabolomics. The combination of LGZ and SIN demonstrate...
KEY FINDING: The combination of LGZ and SIN significantly alleviated pain-like behaviors in CCI rats in a time- and dose-dependent manner, demonstrating superior therapeutic effects compared to LGZ or SIN alone.
Molecular Pain, 2017 • January 1, 2017
The study investigated dendritic spine remodeling in lamina II neurons after spinal cord injury (SCI) in rats exhibiting neuropathic pain. Results showed an inverse relationship between thin- and mush...
KEY FINDING: Total density of dendritic spines on lamina II neurons did not change after spinal cord injury.
Journal of Translational Medicine, 2012 • March 6, 2012
Spinal cord injury (SCI) leads to significant disability, reduced quality of life, and economic burden due to loss of productivity and lifelong supportive care. Neuropathic pain affects a significant ...
KEY FINDING: Cell-based therapies are emerging as promising therapeutic options for spinal cord regeneration and neuropathic pain mitigation after spinal cord injury.
Int. J. Mol. Sci., 2022 • February 28, 2022
This review summarizes the evolving changes in apoptotic and autophagic activities in the injured nerve, dorsal root ganglia, spinal cord, and brain after nerve damage. The crosstalk or interaction of...
KEY FINDING: Upregulated autophagic activities may help myelin clearance, promote nerve regeneration, and attenuate pain behavior after nerve damage.
Journal of Neuroinflammation, 2025 • March 1, 2025
This study investigates the effects of HDAC6 inhibition on neuropathic pain using a spared nerve injury (SNI) mouse model and demonstrates that the selective HDAC6 inhibitor ACY-1215 significantly all...
KEY FINDING: ACY-1215 ameliorated SNI-induced pain starting from Day 7 post-SNI operation, achieving relatively stable efficacy by Day 13 in both male and female mice.
Frontiers in Cellular Neuroscience, 2021 • November 25, 2021
This study investigates the role of TNF-α in trigeminal neuralgia (TN) by examining its effects on MAPKs phosphorylation and BKCa channels in the trigeminal nucleus caudalis (TNC). The results show th...
KEY FINDING: TNF-α, CCL2, and CXCL1 are significantly increased in the TNC region of ION-CCI rats, suggesting their involvement in trigeminal neuralgia.