Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 501-510 of 555 results
Communications Biology, 2025 • January 9, 2025
This study uses spatial transcriptomics (ST), single-nucleus RNA-sequencing (snRNA-seq) and bulk RNA-sequencing (bulk RNA-seq) to characterize regional pathological heterogeneity of the spinal cord (S...
KEY FINDING: The study found unique spatial atlases of genes, cell populations, cell-cell cross-talks, signaling pathways, and transcriptional regulatory networks in the spinal cord of neuropathic pain mice compared to sham mice.
Journal of Nanobiotechnology, 2022 • July 1, 2022
This study investigates the therapeutic effect of huc-MSCs-derived exosomes on CFA-induced inflammatory pain in mice. The exosomes were administered intrathecally, and behavioral tests were conducted ...
KEY FINDING: Huc-MSCs-derived exosomes alleviated mechanical allodynia and thermal hyperalgesia in CFA-induced inflammatory pain model.
J Pain, 2008 • September 1, 2008
This study examined the longitudinal relationships between pain-related beliefs, coping, and social support with pain interference and psychological functioning in individuals with spinal cord injury ...
KEY FINDING: Changes in catastrophizing were significantly associated with changes in pain interference and psychological functioning; increased catastrophizing predicted greater pain interference and poorer psychological functioning.
Top Spinal Cord Inj Rehabil, 2012 • January 1, 2012
This study assessed the reliability of the ISCIP classification among clinicians with minimal training, using clinical vignettes. The results showed moderate reliability, with some pain subtypes being...
KEY FINDING: Respondents showed high confidence in identifying the number of pain components, with an average correctness of 86%.
Neurochemical Research, 2025 • March 17, 2025
The study examined the protective effect of DEX on remifentanil-induced hyperalgesia in rats. Remifentanil, while effective for pain relief, can paradoxically increase pain sensitivity. The findings i...
KEY FINDING: DEX administration reduced mechanical allodynia and thermal hyperalgesia in rats experiencing remifentanil-induced hyperalgesia (RIH).
CNS Neuroscience & Therapeutics, 2025 • January 1, 2025
This study investigates the role of Vof16 in nociceptive sensation induced by SNI, revealing that disrupting Vof16 elevates the excitability of neurons but does not independently drive hyperalgesia in...
KEY FINDING: SNI led to the downregulation of Vof16 expression in spinal dorsal horn (SDH) of lumbar enlargement.
Asian Spine J, 2018 • December 1, 2018
This systematic review aimed to determine the prevalence of neck pain (NP) among athletes by analyzing existing literature up to September 2015. The review included six studies with low-to-moderate ri...
KEY FINDING: The review found that neck pain is highly prevalent among athletes, similar to the general population.
Bioengineering, 2025 • February 20, 2025
This study compared lumbopelvic kinematics in individuals with and without low back pain (LBP) before and after fatigue. Repetitive lifting induced fatigue, significantly affecting lumbopelvic kinemat...
KEY FINDING: Fatigue significantly altered lumbopelvic kinematics, specifically anterior/posterior translation and rotation around the z-axis, in both groups.
Cellular and Molecular Neurobiology, 2024 • November 28, 2024
Neuropathic pain after SCI is caused by glial cells, ectopic firing of neurons endings and their intra- and extracellular signaling mechanisms. SCI causes activation of astrocytes and microglia across...
KEY FINDING: Activated astrocytes and microglia are essential for the development and maintenance of SCI-NP.
Spinal Cord, 2014 • June 1, 2014
This case report highlights the successful management of an acute exacerbation of chronic central pain in a tetraplegic patient through a comprehensive, multidisciplinary approach. The treatment plan ...
KEY FINDING: A multidisciplinary approach, addressing various underlying medical issues and psychological factors, is crucial in managing acute exacerbations of chronic central pain in SCI patients.