Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 491-500 of 555 results
J Pain, 2016 • September 1, 2016
This study investigated the analgesic efficacy of vaporized cannabis in patients with neuropathic pain related to spinal cord injury or disease. Participants underwent a randomized, double-blind, plac...
KEY FINDING: Vaporized cannabis provided significant pain relief compared to placebo in participants with neuropathic pain related to spinal cord injury or disease.
PLoS ONE, 2016 • January 28, 2016
The study used a porcine model to test the effects of thoracolumbar fascia injury and movement restriction on fascia thickness and mobility. Injury alone increased fascia thickness and decreased shear...
KEY FINDING: Injury alone caused an increase in fascia thickness and a decrease in shear strain on the non-injured side.
ClinicoEconomics and Outcomes Research, 2014 • October 29, 2014
This study investigated the economic burden of neuropathic pain (NeP) in US adults by assessing healthcare resource utilization (HRU), productivity, and costs associated with varying pain severity lev...
KEY FINDING: Significant differences were observed across pain severity levels for number of comorbidities, prescription medications, physician office visits, and lost productivity.
Journal of Pain Research, 2018 • January 1, 2018
This study investigates factors influencing placebo responses in SCI patients with neuropathic pain using individual patient data from six RCTs. The analysis revealed that sex and baseline pain intens...
KEY FINDING: Larger placebo responses were observed in male subjects with SCI-related neuropathic pain.
PLoS ONE, 2014 • October 3, 2014
This study uses Autofluorescent Flavoprotein Imaging (AFI) to examine changes in spinal dorsal horn metabolic activity in a rat model of nerve-injury induced pain (Seltzer model) and the effect of spi...
KEY FINDING: Neuropathic rats demonstrated an AFI-response to palpation, while naı¨ve rats did not.
Biomedicines, 2023 • May 12, 2023
This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results...
KEY FINDING: hASCs combined with heparin-based hydrogel micropatches enhanced nerve regeneration in a neuropathic pain animal model.
Brain Behav Immun, 2025 • March 1, 2025
This study demonstrates that blocking or deleting the neonatal Fc receptor (FcRn) can alleviate neuropathic pain in mice after sciatic nerve injury. The researchers used efgartigimod, an FcRn blocker,...
KEY FINDING: Efgartigimod, an FcRn blocker, alleviated mechanical allodynia when administered either 7 or 28 days post-CCI.
Heliyon, 2023 • October 13, 2023
The study demonstrated that intravenously administered RIPCs significantly improved neuropathic pain symptoms, specifically thermal hyperalgesia and mechanical allodynia, in rats with partial sciatic ...
KEY FINDING: Intravenous administration of RIPCs was most effective in reducing thermal hyperalgesia and mechanical allodynia in rats with neuropathic pain.
BMC Complementary and Alternative Medicine, 2018 • February 9, 2018
The study examined the effects of repeated electroacupuncture (EA) treatment on neuropathic pain in rats induced by chronic constrictive injury (CCI) of the sciatic nerve. EA treatment was found to al...
KEY FINDING: Repeated EA treatment relieved both mechanical and thermal hyperalgesia in CCI rats, suggesting an analgesic effect.
J Comp Neurol, 2010 • August 1, 2010
This study investigated the impact of peripheral nerve injury on the central projections of DRG neurons expressing GFRs, focusing on GFRα1, GFRα2, and GFRα3 after sciatic nerve injury in rats. The key...
KEY FINDING: Sciatic nerve injury caused a widespread increase in nerve fiber labeling for GFRα1 in the lumbar dorsal horn.