Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 511-520 of 555 results
Brain Stimul., 2014 • March 1, 2014
This study investigates the effects of motor cortex stimulation (MCS) on cortical responses to noxious stimuli in rats with spinal cord lesions (SCL). The results show that MCS suppresses evoked blood...
KEY FINDING: MCS significantly suppressed evoked blood oxygen dependent signals in the primary somatosensory cortex and the prefrontal cortex.
Cell Biol Toxicol, 2025 • January 1, 2025
This study investigates the effect of Comp 6d, a novel SIRT1 activator, on neuropathic pain and explores its mechanisms. The findings suggest that Comp 6d alleviates neuropathic pain by specifically a...
KEY FINDING: Comp 6d alleviates neuropathic pain by specifically activating SIRT1 in the spinal cord, as demonstrated by the abolishment of its effects in SIRT1 knockout mice.
J Spinal Cord Med, 2010 • June 1, 2010
This study compared the use of Verbal Rating Scales (VRS) and Numeric Rating Scales (NRS) for quantifying pain severity in individuals with spinal cord injuries (SCI). The results indicated a weak cor...
KEY FINDING: The study found a weak correlation (rho = 0.38) between VRS and NRS ratings across 1,114 pain ratings.
Cell Communication and Signaling, 2023 • August 6, 2023
Neutrophil-released NETs in the spinal cord contribute to pain development. FMD inhibits NETs formation and NETs-induced neuroinflammation by inhibiting the MAO-B/5-HIAA/GPR35 and MAO-B/ROS pathways i...
KEY FINDING: NETs accumulate in the spinal cord during inflammatory pain, exacerbating neuroinflammation.
Journal of Central Nervous System Disease, 2024 • January 1, 2024
This study demonstrates the surgical procedure and clinical significance of percutaneous endoscope-assisted CL implantation for SCS in managing neuropathic pain. The endoscopic-assisted technique allo...
KEY FINDING: Successful cylindrical lead implantation under endoscopic guidance was achieved in all patients, including those with failed back surgery syndrome, complex regional pain syndrome, and chronic pelvic pain.
Clin J Pain, 2018 • February 1, 2018
This study evaluated the effectiveness of the Vancouver Acute Neuropathic Pain Treatment Guideline (VANPTG) in assessing and diagnosing neuropathic pain (NP) in patients with traumatic spinal cord inj...
KEY FINDING: The incidence of NP was 56% in patients with traumatic SCI during acute hospital care.
Brazilian Journal of Medical and Biological Research, 2017 • January 1, 2017
The study examined the effect of NAC on p-p38 expression and superoxide anion generation (SAG) in the spinal cord of rats with CCI-induced neuropathic pain. CCI led to decreased SFI and increased p-p3...
KEY FINDING: CCI induced a decrease in SFI as well as an increase in p-p38 expression and SAG in the spinal cord.
Spinal Cord Series and Cases, 2019 • April 23, 2019
This international survey of physicians reveals that opioid prescribing practices for chronic pain in persons with spinal cord damage (SCD) often differ from established clinical practice guidelines. ...
KEY FINDING: Most physicians prescribe opioids for intractable pain after SCD, but a significant proportion do not believe in a specific upper limit of opioid dose if the drug is tolerated.
J Spinal Cord Med, 2005 • January 1, 2005
This paper reports on two cases of individuals with spinal cord injury (SCI) who experienced changes in their neuropathic pain in association with smoking. The first individual experienced increased p...
KEY FINDING: The first subject reported increased neuropathic pain when smoking (7/10) compared to when not smoking (4/10), with pain subsiding 30 minutes after smoking cessation.
Am J Case Rep, 2018 • November 19, 2018
This report is a single subject case study of a unique circumstance in which a patient was provided 2 treatment modalities in a manner creating a natural experimental design. Pain reduction was eviden...
KEY FINDING: Pain intensity decreased following SCS placement and CPRP.