Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 521-530 of 555 results
Qual Life Res, 2018 • November 1, 2018
This study compares Ecological Momentary Assessment (EMA) and End-of-Day (EOD) diaries for measuring pain intensity and pain interference in individuals with spinal cord injury (SCI). The results indi...
KEY FINDING: Five days of EOD assessments are needed for excellent reliability in measuring pain intensity, while three days are sufficient for pain interference.
Mol Pain, 2015 • June 11, 2015
This study investigated the involvement of serotonergic and noradrenergic pathways in spinal cord stimulation (SCS)-induced antinociception in rats with spinal nerve injury. The researchers found that...
KEY FINDING: SCS increased the number of serotonergic neurons and activated them in the DRN, suggesting a key role for this area in SCS-induced pain relief.
Scientific Reports, 2025 • January 14, 2025
This study investigates the therapeutic effect of NaHS on neuropathic pain using the spared nerve injury (SNI) model in mice, focusing on astrocytes and glutamate. The findings reveal that NaHS enhanc...
KEY FINDING: SNI induces chronic pain and depressive-like behaviors in mice, evidenced by decreased mechanical pain threshold, thermal pain latency, and reduced exploratory behavior.
JOURNAL OF NEUROTRAUMA, 2018 • November 1, 2018
The study investigated the relationship between plasma GFAPab, CRMP2ab, and neuropathic pain in SCI patients. The presence of plasma GFAPab in the chronic stage of injury does not differentiate betwee...
KEY FINDING: Plasma GFAPab in the chronic stage of SCI does not correlate with neuropathic pain.
Cochrane Database of Systematic Reviews, 2014 • November 1, 2014
This review critically appraised the effectiveness and safety of non-pharmacological interventions for chronic pain in people living with SCI, identifying 16 randomized trials with 616 participants. T...
KEY FINDING: Transcranial direct current stimulation (tDCS) may reduce pain in the short and mid term.
Anesth Analg, 2014 • February 1, 2014
The study examined the effects of spinal cord stimulation (SCS) on neuropathic pain and glial cell activation in rats with spared nerve injury (SNI). The researchers found that 4Hz and 60Hz SCS for 6 ...
KEY FINDING: 4Hz or 60Hz SCS reversed the mechanical withdrawal threshold (MWT) when compared to sham SCS, indicating pain reduction.
Molecular Pain, 2012 • July 29, 2012
This study investigates the effects of neural mobilization (NM) on pain sensitivity in rats with chronic constriction injury (CCI). The results show that NM treatment reduces hyperalgesia and allodyni...
KEY FINDING: Neural mobilization treatment induced an early reduction of hyperalgesia and allodynia in CCI-injured rats, which persisted until the end of the treatment.
Journal of Pain Research, 2016 • August 31, 2016
This study evaluated the relationship between plasma concentrations of cannabinoids and the analgesic response to vaporized cannabis in 42 subjects with central neuropathic pain. The study found dose-...
KEY FINDING: Dose-dependent improvement in pain score was evident across all pain scale elements after administration of vaporized cannabis.
PRS Global Open, 2021 • June 22, 2021
Targeted muscle reinnervation and regenerative peripheral nerve interfaces are increasingly utilized strategies to mitigate phantom and residual limb pain in amputees. In this case report, the authors...
KEY FINDING: The patient reported a decrease in pain score from eight to four upon activation of the nerve stimulator postoperatively.
Journal of Pain Research, 2018 • May 17, 2018
This study introduces an ovine model of neuropathic pain that allows for the investigation of spinal cord stimulation (SCS) mechanisms through behavioral and electrophysiological measures. The model i...
KEY FINDING: Peroneal nerve constriction in sheep produces a reproducible large animal model of persistent neuropathic pain.