Pharmacology Research

KEY FINDING: The study identified 109 active compounds and 5440 prediction targets from Buyang Huanwu Decoction, with 98 active components and 49 related prediction targets being strongly linked to Spinal Cord Injury.

KEY FINDING: Neuropathic pain is highly prevalent in SCI patients, affecting approximately 75% of patients.

KEY FINDING: This clinical trial will be the first to document the safety and efficacy of riluzole as a means of reducing spasticity in patients with chronic SCI.

KEY FINDING: At group-level, the expected joint resistance reduction due to BoNT-A injections was only observed in the MAS (overall resistance).

KEY FINDING: The literature review identified seven studies (five case reports and two case series) that evaluated topical analgesics for SCI-related NP, with all reporting a decrease in NP over time.

KEY FINDING: The study aims to assess the feasibility of recruiting the target population, delivering the drug treatment protocol, maintaining blinding, and retaining participants.

KEY FINDING: The addition of transdermal neostigmine and glycopyrrolate significantly reduced the time to bowel evacuation compared to standard of care alone.

KEY FINDING: Electroacupuncture (EA) at the zusanli acupoint increases adenosine levels in the L4–6 spinal cord of rats.

KEY FINDING: A total of 379 LAN publications were identified, with the majority published in Chinese. The review categorizes these publications based on indications, including motor, glandular, pain, and aesthetic uses.

KEY FINDING: NFE (500 mg/kg) significantly delayed paw withdraw reaction in thermal hyperalgesia test compared to the vehicle group.