Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 111-120 of 525 results
Journal of Pain Research, 2014 • July 28, 2014
The study aimed to evaluate the long-term safety and tolerability of pregabalin in Japanese patients with central neuropathic pain over a 53-week period. The results indicated that pregabalin was gene...
KEY FINDING: A majority of patients (87.4%) experienced at least one treatment-related adverse event, most commonly somnolence, weight gain, dizziness, or peripheral edema.
Annals of Rehabilitation Medicine, 2014 • August 1, 2014
This study investigated the effects of early tamsulosin treatment on bladder function in a spinal cord injury rat model. Researchers measured bladder pressures, contractility, and protein expression l...
KEY FINDING: Tamsulosin treatment decreased acetylcholine-induced bladder contraction in rats with spinal cord injury.
Acta Biomater., 2015 • January 1, 2015
The study assessed the biocompatibility of a coacervate-based drug delivery system in damaged nervous tissue using a rat model of contusive SCI, focusing on the effects of heparin and PEAD on inflamma...
KEY FINDING: The [PEAD:heparin] coacervate did not exacerbate inflammation, glial scarring, or nervous tissue loss, which are hallmarks of spinal cord injury.
Frontiers in Pharmacology, 2024 • June 27, 2024
This review discusses the use of hydrogels combined with neural stem cells (NSCs) for spinal cord injury (SCI) regeneration. It highlights the limitations of endogenous regeneration and the potential ...
KEY FINDING: NSCs secrete active compounds that promote nerve tissue regeneration, improve nerve cell survival, neuroplasticity, and neuroimmune modulation.
BMJ Open, 2016 • June 1, 2016
The SCISSOR study is a clinical trial protocol investigating the use of high-dose ibuprofen to promote recovery after acute traumatic spinal cord injury (SCI). Ibuprofen acts as a 'small-molecule' Rho...
KEY FINDING: Preclinical evidence suggests that ibuprofen, through Rho inhibition, may enhance motor recovery after SCI. Meta-analysis supported this, showing a 20.2% improvement in motor outcome with ibuprofen/indometacin treatment compared to controls.
Clinical Neuropharmacology, 2016 • November 1, 2016
Traumatic brain injury (TBI) is an alteration in brain function, caused by an external force...Traumatic brain injury is a major cause of morbidity and mortality worldwide. Baclofen is a muscle relaxa...
KEY FINDING: Spasticity in TBI is estimated to be between 17% and 50% of patients with moderate to severe TBI that presents increased muscle tone or spasticity.
Korean J Physiol Pharmacol, 2015 • March 1, 2015
This study investigated the synergistic effects of combining morphine and CI-988, a cholecystokinin type B antagonist, on neuropathic pain in rats after spinal cord injury. The results showed that int...
KEY FINDING: Both morphine and CI-988, when given individually, increased the pain threshold in rats with spinal cord injuries.
Journal of Visualized Experiments, 2016 • September 12, 2016
The study presents a protocol to differentiate between immune system suppression and CNS protection for pharmacological interventions in autoimmune demyelination. It utilizes EAE models in mice, combi...
KEY FINDING: The protocol differentiates between treatments that suppress the immune system and those that directly protect the CNS during autoimmune demyelination.
J Pediatr Pharmacol Ther, 2014 • October 1, 2014
This prospective observational study evaluated the incidence of off-label prescribing at a pediatric rehabilitation center, finding that 57% of medication orders were written off-label and 88% of pati...
KEY FINDING: 57% of medication orders were written off-label.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This study examined the association between antispasmodic medication use and neurological and functional outcomes in patients undergoing inpatient rehabilitation after traumatic SCI. The results indic...
KEY FINDING: Patients receiving antispasmodic medications had significantly lower Rasch-transformed motor FIM scores at discharge compared to those not receiving the medications.