Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 121-130 of 525 results
Neural Regeneration Research, 2015 • April 1, 2015
Prazosin is a selective α-adrenergic blocker that preserves the vasoactive actions of the RAS pathways, exerting a less abrupt suppressive effect on resting BP. A clinical trial showed prazosin reduce...
KEY FINDING: Patients experienced a significantly smaller increase in SBP after ejaculation after being administered prazosin compared to placebo (97 ± 34 mmHg vs. 141 ± 46 mmHg, P = 0.02)
Spinal Cord, 2017 • November 29, 2016
This retrospective study investigated the effect of imidafenacin on urodynamic parameters in SCI patients with indwelling bladder catheters. The study found that imidafenacin significantly improved cy...
KEY FINDING: Imidafenacin increased the cystometric volume from 246.0 to 321.5 ml (median, P = 0.002).
Journal of Pain Research, 2015 • September 8, 2015
This case report describes a 59-year-old female with chronic migraines who experienced complete resolution of her headaches after starting low-dose intrathecal ziconotide. The patient had previously t...
KEY FINDING: The patient experienced complete resolution of migraine headaches following the initiation of low-dose intrathecal ziconotide (1 µg/day).
Brain Res, 2015 • November 19, 2015
The goal of this study was to examine the effects of vibration in lean and obese Zucker rats to determine if the elevation in glucose and insulin in obese rats had a significant effect on sensation or...
KEY FINDING: Obese Zucker rats displayed very few changes in sensorineural function as measured by transcutaneous electrical stimulation immediately after vibration exposure.
Evidence-Based Complementary and Alternative Medicine, 2015 • July 28, 2015
This study investigated the neuroprotective effects of Panax ginseng (P. ginseng) after spinal cord injury (SCI) in rats. The results showed that P. ginseng treatment improved locomotor function, redu...
KEY FINDING: P. ginseng treatment resulted in a significant improvement in locomotor function after spinal cord injury in rats.
Acta Biomater, 2016 • January 1, 2016
This study introduces a novel heparin-poloxamer (HP) thermo-sensitive hydrogel for enhanced nerve regeneration in spinal cord injury (SCI). The NGF-HP hydrogel effectively delivered NGF to the injured...
KEY FINDING: NGF-HP hydrogel showed good morphology and stable bioactivity of NGF in vitro, and enhanced the efficiency of NGF cellular uptake without obvious cytotoxicity.
Toxins, 2015 • December 17, 2015
This preclinical study investigated the impact of reducing the number of injection sites for aboBoNTA in treating NDO in a rat model, finding similar inhibiting effects regardless of whether four or e...
KEY FINDING: AboBoNTA significantly decreased maximal pressure in the bladder, regardless of whether it was injected in four or eight sites.
Glia, 2016 • June 1, 2016
This study investigates the protective effects of adrenergic receptor agonists, specifically epinephrine (EPI) and isoprenaline (ISO), on cellular edema induced by hypotonicity and neurotrauma in cort...
KEY FINDING: Epinephrine administration reduces hypotonicity-induced swelling of astrocytes both in vivo and in vitro.
International Journal of Rehabilitation Research, 2017 • January 24, 2017
This pilot study aimed to develop a treatment diary for patients receiving botulinum toxin injections and physiotherapy for spasticity. The diary focused on problems caused by muscle overactivity, tre...
KEY FINDING: Patients found the treatment diary helpful in becoming more involved in their treatment.
Medicine, 2019 • September 1, 2019
This network meta-analysis protocol outlines the methods for assessing the efficacy and safety of different doses of azilsartan medoxomil in patients with hypertension. The study will search multiple ...
KEY FINDING: This study will summarize all available data to provide reliable evidence of the value of different doses of azilsartan medoxomil for hypertension treatment.