Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 171-180 of 525 results
Int J Clin Exp Pathol, 2013 • July 1, 2013
This study investigated the neuroprotective effects of hyperbaric oxygen therapy (HBOT) on spinal cord injury (SCI) in rats, focusing on the iNOS mRNA-iNOS-NO signaling pathway. The results demonstrat...
KEY FINDING: Rats treated with HBOT after SCI showed improved motor function compared to those without HBOT. This was measured using the BBB scoring system and motor evoked potential (MEP).
SCIENTIFIC REPORTS, 2013 • July 17, 2013
The study investigated the effect of fluoxetine on motor recovery in rats with spinal cord injury. Fluoxetine was administered before and after injury to enhance neural plasticity. Results showed that...
KEY FINDING: Fluoxetine treatment markedly improved motor functions in rats after spinal cord injury, as evidenced by improved performance in behavioral tasks such as the Montoya staircase task and horizontal ladder.
Frontiers in Neuroscience, 2015 • September 2, 2015
This study investigates the functionalization of nanoparticles (NPs) with nerve growth factor (NGF) and glial cell-line derived neurotrophic factor (GDNF) to support regeneration in the nervous system...
KEY FINDING: Covalent binding of NGF to PEI-NPs impaired its bio-functionality, while non-covalent binding successfully differentiated PC12 cells.
Crit Rev Phys Rehabil Med, 2013 • January 1, 2013
Spasticity, characterized by increased muscle tone and involuntary contractions, results from conditions affecting the central nervous system and can significantly impair daily activities and quality ...
KEY FINDING: Baclofen is considered a first-line treatment for spasticity, especially in adult spinal cord injuries, acting as a GABAB agonist to reduce muscle excitability.
Korean Journal of Spine, 2012 • March 1, 2012
This case report describes a 32-year-old woman with spinal cord injury who developed metronidazole-induced encephalopathy (MIE) with peripheral polyneuropathy (PPN). Diagnosis was challenging due to t...
KEY FINDING: The patient developed encephalopathy and peripheral polyneuropathy after being treated with metronidazole for a vaginal infection.
The Journal of Spinal Cord Medicine, 2016 • May 1, 2016
This randomized, double-blind, placebo-controlled trial investigated the effects of progesterone and vitamin D on functional outcomes in patients with acute traumatic spinal cord injury (SCI). The stu...
KEY FINDING: Patients receiving progesterone and vitamin D had significantly higher motor powers and sensory function after 6 months of therapy compared to the placebo group.
Frontiers in Pharmacology, 2016 • March 8, 2016
This study investigated the neuroregenerative properties of co-ultraPEALut in a murine model of spinal cord injury (SCI). The findings demonstrated that co-ultraPEALut treatment increased cell prolife...
KEY FINDING: Co-ultraPEALut increased the numbers of both bromodeoxyuridine-positive nuclei and doublecortin-immunoreactive cells in the spinal cord of injured mice, indicating increased cell proliferation and neurogenesis.
International Journal of Clinical Pharmacy, 2021 • October 9, 2020
The study investigated the potential of montelukast, a leukotriene receptor antagonist, to alleviate age-related neurological decline using Norwegian registry data. The results suggested that previous...
KEY FINDING: Previous use of montelukast correlated with improved scores on cognitive or neurological functioning.
Frontiers in Pharmacology, 2021 • May 18, 2021
The study investigated the adverse effects of chronic sulfasalazine (SAS) treatment in mice, focusing on whether these effects are related to the inhibition of system xc−. Two different doses of SAS w...
KEY FINDING: SAS had a negative impact on the survival rate of mice of both genotypes, independent of its inhibitory action on system xc−.
Neural Regeneration Research, 2021 • January 7, 2021
This research investigates the potential of ISP and PAP4 peptides to promote motor functional recovery following peripheral nerve injury, specifically brachial plexus injury, in a rat model. The study...
KEY FINDING: ISP and PAP4 treatments significantly increased the survival of motoneurons in rats with brachial plexus injury.