Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 161-170 of 525 results
Neural Regen Res, 2018 • September 1, 2018
This study investigates the effect of Saikosaponin a (SSa) on nerve regeneration and scar formation following sciatic nerve injury (SNI) in rats. SSa is a molecule with known anti-inflammatory propert...
KEY FINDING: Saikosaponin a (SSa) treatment significantly increased interleukin-10 (IL-10) levels in rats with sciatic nerve injury (SNI) 7 days after injury, indicating an enhanced anti-inflammatory response.
Medical Science Monitor, 2018 • October 18, 2018
The study examined the effects of lycopsamine on apoptosis and functional recovery after SCI in a rat model. The results showed that lycopsamine administration improves locomotory function in SCI rats...
KEY FINDING: Lycopsamine significantly improved locomotory function in SCI rats.
Journal of Neuroinflammation, 2019 • May 8, 2019
The study investigated the use of mineral-coated microparticles (MCMs) for sustained delivery of interleukin-10 (IL-10) to treat spinal cord injury (SCI) in rats. Results showed that MCMs+IL-10 treatm...
KEY FINDING: MCMs effectively delivered IL-10 to the injury site, resulting in elevated IL-10 levels and suppressed inflammatory cytokines.
Spinal Cord Series and Cases, 2019 • January 1, 2019
Osteoporosis and fragility fractures are prevalent and clinically meaningful in the SCI population. Prevention is a critical area of research. Although many osteoporosis medications demonstrate variab...
KEY FINDING: Bisphosphonate therapy after acute SCI may attenuate bone mineral density (BMD) loss in comparison to no treatment if administered acutely after injury.
Molecular Therapy: Methods & Clinical Development, 2021 • December 1, 2021
This study reports the unexpected finding that AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid (CSF). Different AAV serotypes, inclu...
KEY FINDING: AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid.
PLoS ONE, 2012 • June 19, 2012
This study demonstrated that imatinib treatment following spinal cord injury in rats led to significant improvements in functional outcomes, including enhanced locomotor function, sensorimotor integra...
KEY FINDING: Imatinib significantly enhanced hindlimb locomotor function. By day 56 post-injury, 70% of imatinib-treated rats had regained the ability to make uncoordinated weight-supported steps.
International Journal of Ophthalmology, 2012 • April 18, 2012
The study aimed to evaluate the efficacy of topical Natamycin, produced in China, in treating fungal keratitis using a rabbit model. Rabbits with induced keratitis were treated with Natamycin, Natacyn...
KEY FINDING: Natamycin and Natacyn groups showed significantly better ulcer scores compared to the control group on days 10, 15, and 21.
Therapeutics and Clinical Risk Management, 2012 • October 18, 2012
The study aimed to investigate whether the Barthel Index (BI) underestimates the consequences of neurologic lesions when assessing the clinical outcome after Botulinum toxin type A (BoNT-A) injection....
KEY FINDING: The Barthel Index score increased in follow-up assessments, but the increase was small and only slightly significant in stroke subjects.
Exp Neurol, 2013 • March 1, 2013
This study demonstrates that 5-HT pharmacotherapy after a complete spinal transection in the adult rat produced more reorganization in the sensorimotor cortex than would be expected by the transection...
KEY FINDING: Chronic 5-HT pharmacotherapy increased the proportion of cells that responded to stimulation above the level of the lesion in both the HLSM cortex and the FLM cortex.
Top Spinal Cord Inj Rehabil, 2012 • January 1, 2012
This study examined the effects of nicotine on different subtypes of pain following SCI, using a randomized, placebo-controlled crossover trial. The results indicated differential effects of nicotine ...
KEY FINDING: Nonsmokers with SCI experienced a reduction in mixed forms of pain following nicotine exposure.