Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 181-190 of 525 results
Frontiers in Pharmacology, 2021 • April 15, 2021
This study investigates the role of macrophages and PDGFRβ+ pericytes in fibrotic scar formation after spinal cord injury (SCI) in mice. It focuses on the interaction between M2 macrophages and PDGFRβ...
KEY FINDING: Macrophages and PDGFRβ+ pericytes exhibit a closely related spatiotemporal distribution in the injury core after SCI.
Translational Psychiatry, 2021 • April 19, 2021
This study investigates the acute effects of therapeutic and overdose concentrations of lithium on human iPSC-derived cortical neurons using MEA and patch-clamp techniques. The findings reveal that th...
KEY FINDING: Therapeutic concentrations of lithium increase neuronal excitability and network activity in human iPSC-derived cortical neurons.
Frontiers in Pharmacology, 2021 • April 14, 2021
The study investigates the therapeutic potential of SPF-FB, a protein and lipid fraction derived from Arabian Gulf catfish epidermal gel secretion, in treating sciatic nerve crush injury in rats. SPF-F...
KEY FINDING: SPF-FB treatment significantly enhanced neurobehavioral sensory and motor performance in sciatic nerve-injured rats.
Nanomedicine (Lond.), 2021 • August 17, 2021
Secondary injury after SCI offers a therapeutic window for pharmacological treatments to prevent progressive tissue damage and improve functional outcomes. Nanomaterial-based therapeutic strategies sh...
KEY FINDING: Nanomaterials can be used to deliver drugs that protect the blood-spinal cord barrier (BSCB), reducing permeability and preventing immune cell infiltration after SCI.
Pharmaceuticals, 2021 • August 12, 2021
This study investigates the chirality-dependent anti-inflammatory effects of glutathione (GSH) after spinal cord injury (SCI) in an animal model, comparing d-chiral glutathione (D-GSH) and l-chiral gl...
KEY FINDING: D-GSH significantly increased axon regrowth in rats after spinal cord injury compared to L-GSH treatment, suggesting a chirality-dependent regenerative effect.
Acta Pharmacologica Sinica, 2022 • January 1, 2022
This study investigated the role of metformin in myelin preservation and nerve regeneration in a rat model of spinal cord injury (SCI). The results showed that metformin administration improved locomo...
KEY FINDING: Metformin improves locomotor function in SCI rats, reducing neuronal apoptosis and promoting axon regeneration.
Cell Biosci, 2021 • January 1, 2021
This review summarizes current knowledge and challenges in targeted delivery of neurotrophic factors (NTFs) into the central nervous system (CNS), focusing on available approaches like stem cells, vir...
KEY FINDING: Stem cells, viral vectors, and biomaterials have shown promise in delivering NTFs to the CNS.
Neurochemical Research, 2022 • October 18, 2021
This study demonstrates that clemastine, a drug known to promote myelination, can enhance functional recovery in a rat model of spinal cord injury (SCI). The findings indicate that clemastine treatmen...
KEY FINDING: Clemastine treatment significantly improved motor function recovery in rats with SCI, as measured by BBB scoring, sloping board tests, and grid walking analysis.
Endocrine Connections, 2021 • October 22, 2021
This study investigates the evolutionary conservation and functional divergence of two homologous MC3Rs in the allotetraploid frog Xenopus laevis in vitro. The study clarified the interaction between ...
KEY FINDING: xlMRAP2.L/S enhances α-MSH-stimulated xlMC3Rs signaling and reduces their surface expression.
Oxidative Medicine and Cellular Longevity, 2022 • January 7, 2022
The review comprehensively covers the role of oxidative stress, inflammation, and apoptosis in the pathophysiology of SCI. It emphasizes the interconnectedness of these pathways and the need for multi...
KEY FINDING: Polyphenols can modulate neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in SCI.