Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 11-20 of 525 results
Biomedicines, 2023 • April 10, 2023
This study describes seven cases of spontaneous intramuscular hematomas (SMHs) in patients with spinal cord injuries (SCIs) undergoing rehabilitation. The patients were either receiving anticoagulant ...
KEY FINDING: Intramuscular hematomas are rare complications after SCI, often presenting as sudden limb swelling.
Experimental Biology and Medicine, 2023 • April 1, 2023
This study demonstrates that ALA increases GABAAR-mediated inhibitory activity in the BLA and CA1 pyramidal neurons 24 h after injection in young adult Sprague-Dawley male rats. The study showed that ...
KEY FINDING: Administration of ALA increased the charge transfer of inhibitory postsynaptic potential currents mediated by GABAA receptors in pyramidal neurons in the BLA and CA1 compared to vehicle animals.
Acta Pharmaceutica Sinica B, 2023 • May 1, 2023
This study introduces a novel approach for treating CNS injuries, particularly stroke, by utilizing engineered extracellular vesicles (EVs) derived from M2 microglia. The EVs are modified with DA7R an...
KEY FINDING: Dual-EV nanocarriers target human umbilical vascular endothelial cells (HUVECs) and recruit NSCs in vitro.
MOLECULAR MEDICINE REPORTS, 2023 • April 25, 2023
Porous GMSs were synthesized using a simple FGF10‑encapsulating procedure. More specifically, GMSs loaded with FGF10 were administered to SCI rats; FGF10 was then slowly released at the site of injury...
KEY FINDING: FGF10-GMS treatment led to superior outcomes in terms of neuroprotection, motor function and morphological recovery compared with FGF10 treatment.
Neural Regen Res, 2024 • May 31, 2023
This review discusses the role of spinal cord microcirculation in spinal cord injury, including its structure and histopathological changes. It summarizes the progress of drug therapies targeting the ...
KEY FINDING: Neurotrophic factors like diencephalon astrocyte derived neurotrophic factor and cerebrolysin can reduce abnormal permeability of the blood-spinal cord barrier and improve functional recovery.
Neural Regeneration Research, 2024 • February 1, 2024
This review discusses the advances in EV-based combination therapies for SCI, specifically when EVs are combined with nanoparticles, exogenous drugs, and biomaterials. These combinations aim to improv...
KEY FINDING: Combining EVs with nanoparticles, such as iron oxide nanoparticles (IONP), can improve their targeting ability to the injured spinal cord tissue, especially when guided by an external magnetic field.
PM R, 2023 • December 1, 2023
This study represents the first assessment of pharmacologic management of AD since the definition was formalized and clinical practice guidelines were published. Most physicians had formalized AD mana...
KEY FINDING: The majority of physicians (69%) had a formal AD management protocol for inpatient care, with nitroglycerin ointment (82%) being the most common first-line medication.
Spinal Cord Series and Cases, 2023 • January 1, 2023
This document is a correction to a published case report. The correction addresses an error in the description of Baclofen's mechanism of action. The initial publication misidentified Baclofen as a GA...
KEY FINDING: The original article incorrectly stated that Baclofen is a GABA receptor antagonist.
Frontiers in Pharmacology, 2023 • September 20, 2023
The study uses a systems pharmacology approach to identify a four-drug combination (IL-6, HU-210, Taxol, and APC) that promotes axonal regeneration after injury in the rat optic nerve crush model. The...
KEY FINDING: The combination of IL-6 and HU-210 stimulates neurite outgrowth in an inhibitory environment by promoting neuroprotection and enabling neurite outgrowth.
Frontiers in Neuroscience, 2023 • October 10, 2023
This review assesses the potential of astaxanthin (AST) for treating spinal cord injury (SCI) in rats, focusing on neurological roles and clinical translation potential. Meta-analyses revealed that AS...
KEY FINDING: AST treatment in rats with SCI shows increased Basso, Beattie, and Bresnahan (BBB) scores, indicating improved locomotor function recovery compared to controls.