Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 21-30 of 525 results
Top Spinal Cord Inj Rehabil, 2023 • July 1, 2023
This study investigated the effects of salsalate on fasting and postprandial glycemic, lipidemic, and inflammatory responses in persons with tetraplegia. The main findings were that salsalate signific...
KEY FINDING: Salsalate significantly reduced fasting and postprandial glucose values in persons with tetraplegia.
JBMR Plus, 2023 • December 1, 2023
The study demonstrates the efficacy of Siglec-15 Ab (NP159) in reducing bone resorption after acute SCI while maintaining bone formation capacity in rats. NP159 almost fully prevents the SCI-induced l...
KEY FINDING: NP159 treatment almost completely prevents the deterioration of bone after SCI, including loss of bone mineral density, trabecular bone volume, trabecular connectivity, and bone stiffness.
Journal of Nanobiotechnology, 2024 • December 6, 2023
This study developed electroconductive hydrogels composed of tannic acid (TA) and polypyrrole (PPy), incorporating exosomes with immunomodulatory properties to enhance spinal cord injury (SCI) repair....
KEY FINDING: M2-Exos-laden electroconductive hydrogels stimulate the growth of neural stem cells and axons in the dorsal root ganglion and modulate microglial M2 polarization.
bioRxiv preprint, 2023 • December 14, 2023
The study demonstrates that a triple combination formulation (TCF) containing the HDAC inhibitor vorinostat can effectively treat chronic neuropathic pain in a spared nerve injury (SNI) rat model. A s...
KEY FINDING: A single injection of the TCF significantly reduced mechanical allodynia (pain from normally non-painful stimuli) for up to four weeks in SNI rats.
BMC Pharmacology and Toxicology, 2024 • January 1, 2024
This study examined the efficiency of fixed-dose enoxaparin for VTE prophylaxis in rehabilitation patients after SAIS or SCI. The study found that a fixed dose may be inadequate for a significant prop...
KEY FINDING: Fixed-dose enoxaparin prophylaxis resulted in sub-prophylactic anti-Xa levels in 19% of patients and supra-prophylactic levels in 7.9% of patients.
Pharmaceuticals, 2024 • January 4, 2024
This study was an open label, single arm, prospective pilot study to evaluate the feasibility of treating people with TSCI with oral selenium and vitamin E. Four subjects completed the full twelve-mon...
KEY FINDING: Combination treatment with vitamin E and selenium was demonstrated as safe for TSCI patients, with no adverse events related to study medications.
Cells, 2024 • February 27, 2024
This review summarizes the combinatorial effects of rehabilitation and various medical agents in spinal cord injury (SCI) treatment, based on 43 articles. The medical agents are categorized into neuro...
KEY FINDING: Rehabilitation promotes various recovery processes, including regeneration of tracts, neuroprotection, scar tissue reorganization, plasticity of spinal circuits, and enforcement of the musculoskeletal system, which can be enhanced by medication.
Cureus, 2024 • February 12, 2024
This case report highlights the efficacy of a tailored physiotherapy rehabilitation approach in restoring function in a patient with quadriparesis following cervical spine trauma. The successful outco...
KEY FINDING: The patient demonstrated significant improvements in muscle strength, joint range of motion, and overall functional abilities through the rehabilitation program.
Advanced Science, 2024 • March 21, 2024
The study introduces a novel nano complex designed for targeted repair of spinal cord injuries (SCI). The nano complex, consisting of a microRNA-loaded core camouflaged by a stem cell membrane modifie...
KEY FINDING: The nano complex promotes axon regrowth, modulates the local inflammatory microenvironment, and enhances functional recovery of SCI in mice, without causing treatment-related secondary injury.
Drug Design, Development and Therapy, 2024 • April 29, 2024
This paper provides a comprehensive review of the potential molecular biology mechanisms of hydrogen therapy and its application in treating SCI. Hydrogen has been proven to possess anti-inflammatory,...
KEY FINDING: Hydrogen exhibits selective antioxidant action by eliminating excessive harmful free radicals and alleviating cellular damage, thereby promoting recovery from conditions such as cerebral ischemia.