Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 161-170 of 292 results
Nat Mater., 2011 • December 1, 2011
The study demonstrates a novel electrochemical method for modulating nerve activity by using ion-selective membranes (ISMs) to control ion concentrations in situ. The use of ISMs allows for both the r...
KEY FINDING: Calcium ion depletion using ISMs can reduce the electrical threshold for nerve stimulation by approximately 40%.
Frontiers in Neurology, 2017 • June 20, 2017
We have demonstrated that, in SCI, multifrequency EIM patterns differ substantially from those in healthy control subjects at biceps brachii, especially the reactance and phase angle. Our results reve...
KEY FINDING: The results showed that there was a significant decrease in muscle reactance (X) and phase angle (θ) at selected frequencies (i.e., 50 and 100 kHz) in SCI compared to control.
Biochemistry and Biophysics Reports, 2017 • January 17, 2017
This study investigates the effects of myostatin and an ALK4/5/7 inhibitor (SB431542) on miRNA expression in differentiating C2C12 myoblasts to understand the regulation of muscle-specific and highly ...
KEY FINDING: Myostatin (1 µg/ml) reduced the expression of miR-1 and miR-133a at 1 day post-differentiation induction but not at 3 days.
Frontiers in Physiology, 2017 • July 18, 2017
The study investigated the use of heart rate variability (HRV) to diagnose neuropathic pain (NP) in individuals with spinal cord injury (SCI). The results indicated that participants with SCI and NP e...
KEY FINDING: SCI+NP participants demonstrated lower overall HRV, as determined by the SDNN time domain parameter, compared to either AB (p < 0.01) or SCI-NP (p < 0.05) groups.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This mini-review presents evidence for TRT as a potential strategy to aid in the management of body composition changes and to improve metabolism in persons with SCI. In the absence of adequate studie...
KEY FINDING: Transdermal TRT can increase LBM and reduce FM over 3–36 months, relative to placebo, in hypogonadal elderly men and to a lesser extent in men with SCI.
Arch Phys Med Rehabil, 2018 • March 1, 2018
This study evaluated the effects of pressure threshold respiratory training (RT) on heart rate variability and baroreflex sensitivity in persons with chronic spinal cord injury (SCI). The results indi...
KEY FINDING: Respiratory training significantly increased FVC and FEV1 in the RT group compared to controls.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This cross-sectional study assessed the associations between respiratory symptoms and plasma vitamin D and measures of body fat in individuals with chronic SCI. The study found that increased body fat...
KEY FINDING: Increased body fat (android, gynoid, trunk, or total body fat) was associated with increased odds ratios for any wheeze and suggestive associations with persistent wheeze, but not with chronic cough or phlegm.
Respir Physiol Neurobiol, 2018 • October 1, 2018
This study demonstrates that spinal PKC activation elicits pMF, an effect prevented by pretreatment with two PKC inhibitors that differ in their mechanism of action and isoform specificity: BIS and NP...
KEY FINDING: Spinal PKC activation via intrathecal PMA elicits pMF.
J Physiol, 2018 • December 20, 2017
The study examined the impact of disuse and retraining on lower limb muscle power in young and older adults. Disuse led to a significant decrease in MEP in older adults, while retraining was insuffici...
KEY FINDING: Disuse significantly decreased maximal explosive power (MEP) in older adults but not significantly in young adults.
Top Spinal Cord Inj Rehabil, 2017 • January 1, 2017
This article reviews the impact of spinal cord injury (SCI) on sexual function, covering the basic anatomy and physiology of sexual responses, the pathophysiology of sexual dysfunction following SCI, ...
KEY FINDING: Peripheral nerves in the pelvis are regulated by cerebral control, and SCI can disrupt this control, impacting both psychological and reflex responses for genital arousal, ejaculation, and orgasm.