Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 261-270 of 292 results
PLoS ONE, 2018 • June 27, 2018
This study assessed the association between circulating adipo-myokines and lean mass in 205 men with chronic SCI, finding a significant positive association between lean mass and leptin, independent o...
KEY FINDING: There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat.
Angiogenesis, 2018 • May 1, 2018
This study investigates the impact of chronic mild hypoxia (CMH) on vascular remodeling in the spinal cord, revealing that CMH promotes endothelial proliferation, angiogenesis, and arteriogenesis. The...
KEY FINDING: Chronic mild hypoxia (CMH) promotes endothelial proliferation and increased vascularity in spinal cord blood vessels through angiogenesis and arteriogenesis.
Spinal Cord, 2018 • October 1, 2018
This study evaluated the reproducibility of total and regional DXA-derived body composition values in individuals with spinal cord injury (SCI). The study assessed both short-term (same day) and long-...
KEY FINDING: Short-term precision: The RMS-CV% for each region did not exceed 5.6%, 2.7%, 3.8%, 6.5%, 5.8% and 2.3% for arms, legs, trunk, android and gynoid regions and total body mass, respectively.
Circ Res, 2015 • June 5, 2015
The autonomic nervous system intricately modulates nearly all physiological functions of the heart. Cardiac autonomic dysregulation is central to the development and progression of most cardiovascular...
KEY FINDING: Cardiac injury leads to abnormal signaling in the nervous system, resulting in excessive sympathetic activity and potentially fatal arrhythmias.
J Rehabil Res Dev, 2008 • January 1, 2008
Individuals with SCI experience musculoskeletal deterioration, including muscle atrophy and bone demineralization, due to the loss of physiological stress to tissues. Electrical muscle stimulation can...
KEY FINDING: Chronic SCI leads to a transformation of muscle fibers from slow, fatigue-resistant to fast, fatigable types, accompanied by biochemical changes.
The Journal of Spinal Cord Medicine, 2019 • July 1, 2019
This study evaluated the accuracy of DXA in quantifying trunk lean mass compared to MRI in men with SCI. The results showed that DXA overestimated trunk lean mass when compared to MRI. The study also ...
KEY FINDING: DXA overestimated trunk lean mass compared to MRI measurements. Trunk LM-DXA (24 ± 3.3 kg) and android LM-DXA (3.6 ± 0.7 kg) overestimated (P < 0.0001) trunk LM-MRI (1.7 ± 0.5 kg).
Journal of Cellular Physiology, 2022 • March 1, 2022
The study investigates the effect of inflammatory stimuli and bile acids on myelin clearance by macrophages. Activation of the LPS-TLR4/NFκB pathway reduces myelin phagocytosis by bone marrow-derived ...
KEY FINDING: Activation of the TLR4-NFκB pathway reduced myelin uptake by bone marrow-derived macrophages (BMDM), while IFNγ-Jak/STAT1 signaling did not.
BMC Neurology, 2006 • March 15, 2006
This case report describes a 63-year-old woman who presented with progressive triplegia following a road traffic accident, initially raising suspicion for cervical spinal cord injury. However, further...
KEY FINDING: The patient's symptoms of progressive triplegia initially suggested cervical spinal cord injury, but detailed evaluation revealed a cerebrovascular etiology.
Biology Open, 2013 • January 1, 2013
This study demonstrates that optogenetics can be used to initiate regeneration of a complex vertebrate structure in vivo by light-gated H+ pump, Archaerhodopsin. Light-activated Arch activity restores...
KEY FINDING: Light activation of Archaerhodopsin (Arch) hyperpolarizes cells in vivo, rescuing Xenopus embryos from craniofacial and patterning abnormalities.
Anat Rec (Hoboken), 2012 • October 1, 2012
This study provides a histological comparison of the mature regenerated and original tail of the lizard Anolis carolinensis. The regenerated tail has a cartilage skeleton enclosing a spinal cord but l...
KEY FINDING: The regenerated tail has a cartilage tube with foramina, enclosing a spinal cord with an ependymal core, but no regeneration of dorsal root ganglia or peripheral nerves.