Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 111-120 of 2,317 results
Cells, 2022 • September 5, 2022
This study investigates the therapeutic potential of human induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs) for treating cervical spinal cord injury (SCI) in rats. The key fin...
KEY FINDING: iPSC-NPCs were able to survive and differentiate into both neurons and astrocytes after transplantation into a cervical contusion SCI rat model.
in vivo, 2022 • July 12, 2022
This study investigates methods for culturing olfactory ensheathing cells (OECs) using materials and reagents certified for pharmaceutical use, aiming to produce advanced cell therapies for humans wit...
KEY FINDING: Acid-solubilized collagen (ASC) is superior to pepsin-solubilized collagen (PSC) for creating 3D collagen scaffolds, as ASC provides easier handling during surgical procedures.
Journal of Immunology Research, 2022 • September 12, 2022
This paper argues that a miR-34a-3p/PDCD6 axis might be a candidate therapeutic target for treating SCI and that the therapeutic effect of EA is driven through this pathway. The results revealed that m...
KEY FINDING: miR-34a-3p might promote the in vitro differentiation of neural stem cell (NSC) through suppressing PDCD6 and regulating other important neural markers such as fibroblast growth factor receptor 1 (FGFR1), MAP1/2 (MAP kinase kinases 1/2), myelin basic protein (MBP), βIII-tubulin Class III β-tubulin (βIII tubulin), and glial fibrillary acidic protein (GFAP).
Molecular Medicine, 2022 • September 12, 2022
miR-21 has potential against the burden of SCI through suppressing the inflammatory milieu in neural cells, apoptosis inhibition, improving angiogenesis, and synapsis protection. Current understanding...
KEY FINDING: miR-21 overexpression reduces neuroinflammation after SCI by decreasing the expression of inflammatory factors.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
The Ernest Bors, MD Award for Scientific Development is awarded annually by the Journal of Spinal Cord Medicine to recognize excellence in spinal cord injury research. Nathan Hogaboom, PhD, received t...
KEY FINDING: Dr. Hogaboom's pilot study evaluates micro-fragmented adipose tissue injection under ultrasound guidance for treating refractory rotator cuff disease in wheelchair users with spinal cord injury.
Neural Regen Res, 2020 • March 1, 2020
The central nervous system is known to have limited regenerative capacity. Not only does this halt the human body’s reparative processes after central nervous system lesions, but it also impedes the e...
KEY FINDING: Stem cell-derived exosomes have been found to promote tissue repair and regeneration, while it is believed that exosome inclusions induce epigenetic changes in the recipient’s cells, positively regulating their fates by promoting proliferation or inhibiting apoptosis.
Theranostics, 2019 • September 21, 2019
This study introduces a novel injectable hydrogel (Lap/Hep@FGF4) designed for sustained release of FGF4 at the site of spinal cord injury (SCI). The hydrogel is composed of heparin and Laponite, which...
KEY FINDING: The Lap/Hep@FGF4 group showed remarkable motor functional recovery and axonal regrowth after SCI through suppressing inflammatory reaction, increasing remyelination and reducing glial/fibrotic scars.
Neural Regeneration Research, 2020 • December 10, 2019
This review addresses why some neurons regenerate better than others, focusing on intrinsic regenerative capabilities and responses to environmental factors. The study emphasizes the utility of non-ma...
KEY FINDING: Neurons exhibit varying intrinsic regenerative capabilities, influenced by factors like mTOR activity and the expression of specific proteins such as osteopontin.
The Journal of Clinical Investigation, 2020 • March 16, 2020
Using models with different regenerative capacities, followed by gain- and loss-of-function analysis, we identified profilin 1 (Pfn1) as a coordinator of actin and microtubules (MTs), powering axonal ...
KEY FINDING: Pfn1 activity increases after CL, suggesting it's important for actin dynamics in the axonal tip and for growth competence.
Neural Regen Res, 2020 • January 28, 2020
Spinal cord injury is linked to the interruption of neural pathways, which results in irreversible neural dysfunction. There is increasing evidence to suggest that neuromagnetic/electrical modulation ...
KEY FINDING: Neuromodulation techniques, such as noninvasive magnetic stimulation and electrical stimulation, have been safely applied in many neuropsychiatric diseases.