Regenerative Medicine & Stem Cells Research

KEY FINDING: The protocol provides a unified method for extracting NSCs from three neurogenic niches: the subventricular zone (SVZ), subgranular zone (SGZ), and central canal (CC).

KEY FINDING: Clearance of the lesion core (via suction of cystic tissues and trimming of solid scar tissues) before introducing NT3-chitosan led to robust neural regeneration and functional recovery.

KEY FINDING: Apelin expression decreases after SCI and then increases later, suggesting its involvement in both injury and repair.

KEY FINDING: Spontaneous recovery after SCI follows a pattern of early intra-hemispheric reorganization followed by late inter-hemispheric reorganization, while regenerative therapy shows the opposite trend.

KEY FINDING: BSHX decoction improved motor function recovery in SCI mice.

KEY FINDING: The patient's ASIA Impairment Scale improved from ASIA A to ASIA C following OEC transplantation and neurorehabilitation.

KEY FINDING: Regular exercise led to a significant reduction in pain hypersensitivity in rats with CCI at 5 weeks post-injury.

KEY FINDING: Voluntary treadmill training did not enhance forelimb recovery in mice after cervical SCI, regardless of whether they were administered GBP or vehicle.

KEY FINDING: Combinational therapy of BMMSCs and PEMF displayed a more satisfactory effect than BMMSCs and PEMF therapy alone in SCI mice.

KEY FINDING: The combination of rehabilitation and NPC grafting significantly improved functional recovery in rats with chronic SCI, whereas either treatment alone was not effective.