Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 121-130 of 2,317 results
Sci. Adv., 2020 • April 1, 2020
This study introduces SHIELD, an injectable hydrogel designed to improve the survival and therapeutic function of transplanted Schwann cells for spinal cord injury treatment. SHIELD addresses key chal...
KEY FINDING: SHIELD hydrogels provide protection from membrane damage during syringe needle injection, improving cell survival during transplantation.
Cells, 2020 • May 25, 2020
This study aimed to examine changes in neuronal DNA methylation status after SCI and to determine whether modulation of DNA methylation with ascorbic acid can enhance neuronal regeneration or function...
KEY FINDING: SCI induces alteration of 5mC and 5hmC Levels in the Brain Motor Cortex. The intensity of 5hmC was significantly higher in the SCI group than in the control group at 1 day (acute stage) and 1 week after injury.
Cell Death & Disease, 2020 • June 1, 2020
This review summarizes recent progress in biological and engineering strategies for reconstructing neural circuits and promoting functional recovery after SCI, emphasizing current challenges and futur...
KEY FINDING: Gene regulation of neural regeneration, cell or cell-derived exosomes and growth factors transplantation, repair of biomaterials, and neural signal stimulation lead to axonal regeneration and neural circuit reconstruction.
Neurotherapeutics, 2020 • August 27, 2020
This study investigates the potential of repetitive trans-spinal magnetic stimulation (rTSMS) as a noninvasive treatment for spinal cord injury (SCI) in mice, focusing on tissue repair and functional ...
KEY FINDING: rTSMS modulates the lesion scar by decreasing fibrosis and inflammation, suggesting it promotes a more permissive environment for regeneration.
Cell Transplantation, 2020 • January 1, 2020
This study investigated the safety and efficacy of using NeuroRegen scaffolds combined with autologous bone marrow mononuclear cells (BMMCs) to treat acute complete spinal cord injury (SCI). Seven pat...
KEY FINDING: Implantation of NeuroRegen scaffolds combined with BMMCs appeared safe, with no adverse events related to the scaffold or stem cell implantation observed during the 3-year follow-up.
eLife, 2020 • September 7, 2020
This study demonstrates evidence for a receptor-mediated signaling role for complement C1q in the CNS, modulating NSC migration, proliferation, and lineage commitment. The study defines and validates ...
KEY FINDING: C1q activates specific intracellular signaling pathways in NSC to modulate NSC behavior.
Neural Regeneration Research, 2021 • March 1, 2021
Cell transplantation holds promise for treating spinal cord injury (SCI) due to the inadequacies of current treatments. Stem cells, macrophages, and Schwann cells offer potential for nerve regeneratio...
KEY FINDING: Neural stem cell (NSC) transplantation has shown improvements in motor and sensory function in some patients with thoracic SCI, suggesting the potential of allogeneic NSCs.
Cells, 2020 • November 6, 2020
The study aimed to identify the origins of early regenerating axons in lampreys after spinal cord injury, as these axons contribute to early functional recovery. BABB clearing significantly improved t...
KEY FINDING: Over 50% of the early regenerating axons belonged to small neurons in the brainstem, specifically in the posterior and middle rhombencephalic reticular nuclei (PRRN and MRRN).
Frontiers in Cellular Neuroscience, 2020 • October 14, 2020
Neural stimulation modulates the depolarization of neurons, thereby triggering activity-associated mechanisms of neuronal plasticity. New research has uncovered genetic mechanisms that govern the expr...
KEY FINDING: Patterns of depolarization in neurons are shown to be important mediators of genetic expression patterns and molecular responses.
BioMed Research International, 2020 • December 7, 2020
This study investigates the combined effect of ultrashort wave (USW) therapy and human umbilical cord mesenchymal stem cell (HUC-MSC) transplantation on spinal cord injury (SCI) in rats. The combinati...
KEY FINDING: The combination of USW and HUC-MSCs significantly improved motor function in SCI rats, with USW playing a more prominent role.