Regenerative Medicine & Stem Cells Research

KEY FINDING: SWT reduces reactive oxygen species and apoptosis in human neurons subjected to ischemic injury.

KEY FINDING: GPNMB promotes neuronal viability and differentiation, as evidenced by increased expression of βIII tubulin and CNPase.

KEY FINDING: NSC-EVs can modulate various physiological and pathological processes, including neuroinflammation, neuroprotection, BBB integrity maintenance, neuroregeneration, and neurogenesis.

KEY FINDING: SWT markedly improved locomotor function in WT animals in comparison with untreated control animals, whereas SWT had no effect in Tlr3-deficient mice.

KEY FINDING: PD markedly facilitated BMSC differentiation into neuron-like cells by activating the Nrf2 pathway and increased the expression of neuronal markers in the transplanted BMSCs at the injured spinal cord sites.

KEY FINDING: Rehabilitative training promoted the survival rate and neuronal differentiation of transplanted hiPSC-NS/PCs in the chronic SCI model.

KEY FINDING: Wnt5a and miRNA200b-3p promote NSC differentiation into neurons, with Wnt5a upregulating miRNA200b-3p expression through the MAPK/JNK pathway.

KEY FINDING: Sustained expression of NT3 and SHH significantly increased the growth of regenerating axons into the implanted bridge and enhanced their myelination after eight weeks.

KEY FINDING: MSCs exert immunomodulatory effects by secreting enzymes and soluble factors that act on various T lymphocytes, B cells, NK cells, and myeloid cells, disrupting their activation, proliferation, maturation, cytolytic activity, cytokine production, or antibody production.

KEY FINDING: Lithium plus reimplantation therapy significantly improved the grasping strength of the injured forepaw.