Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 171-180 of 2,317 results
PLoS ONE, 2014 • August 26, 2014
The study investigates the temporal relationship between swimming ability and regenerated cerebrospinal axon number in adult zebrafish with a complete spinal cord transection. Swimming ability gradual...
KEY FINDING: Swimming ability in zebrafish gradually improves between two and eight weeks after a spinal cord transection, reaching 44% of sham-injured fish.
Journal of Translational Medicine, 2014 • September 2, 2014
This study evaluated the efficacy of umbilical cord mesenchymal stem cell (UCMSC) transplantation for treating sequelae of thoracolumbar spinal cord injury, comparing it to rehabilitation therapy and ...
KEY FINDING: UCMSC transplantation significantly improved motor function in patients with spinal cord injury sequelae.
Journal of Biological Chemistry, 2014 • November 21, 2014
This study investigates the therapeutic potential of induced neural stem cells (iNSCs) for spinal cord injury (SCI) in a rat model. The findings demonstrate that engrafted iNSCs can differentiate into...
KEY FINDING: Engrafted iNSCs can differentiate into all neuronal lineages, including different subtypes of mature neurons, and form synapses with host neurons.
Cell and Tissue Research, 2022 • November 25, 2021
Rodent studies tracing endogenous NSCs in injuries and disease have revealed diversified roles for these cells depending on the model system. In SCI-based models, many endogenous NSCs have been found ...
KEY FINDING: Endogenous NSCs can contribute to reactive gliosis by differentiating into reactive astrocytes, while in other models, they can provide new myelination and neural replacement.
Journal of Visualized Experiments, 2014 • October 14, 2014
The study presents a detailed protocol for performing complete spinal cord transections in larval sea lampreys and subsequent brain dissection for wholemount in situ hybridization. The protocol includ...
KEY FINDING: The protocol demonstrates a reliable method for complete spinal cord transection in larval sea lampreys.
Neural Regeneration Research, 2014 • October 1, 2014
This study investigated the synergistic effects of olomoucine and GDAsBMP in treating spinal cord injury in rats. A rat model of acute spinal cord contusion was established, and the treatments were ad...
KEY FINDING: Olomoucine effectively inhibited astrocyte proliferation and the formation of scar tissue at the injury site, but did not prevent proliferation of GDAsBMP or inhibit their effects in reducing the spinal cord lesion cavity.
Scientific Reports, 2016 • August 3, 2016
This study demonstrates that combined therapy with NS/PC transplantation and treadmill training promotes functional recovery in chronic SCI animal models. NS/PC transplantation enhances electrophysiol...
KEY FINDING: The combination of NS/PC transplantation and treadmill training resulted in significant locomotor recovery compared to the control group in mice with chronic SCI.
Nature, 2015 • February 19, 2015
This study investigates the role of PTPσ in inhibiting nerve regeneration after spinal cord injury (SCI). A peptide mimetic (ISP) targeting PTPσ was developed and tested for its ability to promote rec...
KEY FINDING: PTPσ stabilizes growth cones within CSPG-rich substrates, contributing to axonal dystrophy.
Brazilian Journal of Medical and Biological Research, 2016 • September 1, 2016
The study investigated the effectiveness of stem cells from human exfoliated deciduous teeth (SHEDs) transplantation combined with treadmill training in rats with experimental spinal cord injury (SCI)...
KEY FINDING: SHEDs treatment alone or in combination with treadmill training promoted functional recovery, with BBB scores significantly higher than the SCI group.
Scientific Reports, 2016 • September 27, 2016
This study investigates the role of HB-GAM in reversing the inhibitory effects of the CNS extracellular matrix on neural regeneration. It demonstrates that HB-GAM promotes neurite outgrowth by interac...
KEY FINDING: HB-GAM promotes neurite outgrowth on CSPG substrates, overcoming the inhibitory effects of aggrecan, neurocan, and brain-derived CSPGs.