Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 151-160 of 2,317 results
Stem Cells Translational Medicine, 2023 • March 9, 2023
NSPC transplantation represents a promising strategy for the regeneration of the injured spinal cord due to the ability of these cells to replace neural cells lost post-injury. We suggest using combin...
KEY FINDING: Integration is an important challenge related to neural stem/progenitor cell transplantation.
Stem Cell Investigation, 2023 • March 10, 2023
The review discusses the current status of regenerative medicine for spinal cord injury (SCI) using human induced pluripotent stem cells (iPSCs), highlighting the potential of iPSC-derived neural stem...
KEY FINDING: Transplanted iPSC-NS/PCs can engraft into the host spinal cord and differentiate into neurons, astrocytes, and oligodendrocytes, contributing to the reconstruction of neuronal circuits.
Front. Bioeng. Biotechnol., 2023 • March 13, 2023
Spinal cord injury (SCI) leads to sensory and motor dysfunction, with limited treatment options. Cell therapy shows promise but faces challenges. Exosomes, as paracrine factors released by cells, have...
KEY FINDING: Stem cell-derived exosomes have anti-inflammatory effects and can play a role in SCI treatment.
Cell Transplantation, 2023 • August 21, 2023
This study demonstrates that cryopreserved olfactory ensheathing cells (OECs) can restore lost function in rats with dorsal root injuries, comparable to primary cultured OECs. The transplantation of c...
KEY FINDING: Transplantation of cryopreserved rat olfactory bulb OECs encapsulated in collagen restored the loss of function in a vertical climbing test in a unilateral C6-T1 dorsal root injury model.
Top Spinal Cord Inj Rehabil, 2023 • January 1, 2023
Translating regenerative therapies for spinal cord injury faces numerous hurdles, including the limitations of animal models, differences in injury characteristics, and the need for combinatorial trea...
KEY FINDING: Species differences, particularly in lesion characteristics, anatomy, and metabolism, pose significant challenges to translating findings from rodent models to humans with spinal cord injury.
J Comp Neurol, 2020 • June 15, 2020
This study investigated the molecular and histologic responses to spinal cord injury (SCI) in spiny mice (Acomys cahirinus) compared to C57BL/6 mice (Mus). Gene array and RT-qPCR results showed that s...
KEY FINDING: Spiny mice showed increased expression of genes related to neurogenesis and regeneration after spinal cord injury compared to C57BL/6 mice.
Journal of Orthopaedic Translation, 2020 • November 11, 2019
The Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019) aim to provide a therapeutic standard for clinicians and researchers to restore functions in patien...
KEY FINDING: Early decompression and stabilization (within 24 hours) after acute SCI can improve neurological outcomes, shorten hospitalization, and reduce complications.
J Cell Mol Med, 2020 • January 1, 2020
This study aimed to investigate the role of miR-30b in promoting sensory function recovery after spinal cord injury (SCI) by enhancing primary sensory neuron (PSN) axon growth. The results demonstrate...
KEY FINDING: MiR-30b promotes primary sensory neuron axon growth in vitro by targeting and degrading sema3A mRNA.
Journal of Cerebral Blood Flow & Metabolism, 2021 • February 1, 2021
The review discusses the potential of targeting axon guidance molecules, especially Wnts, to promote neural circuit repair after spinal cord injury. It highlights that Wnt signaling inhibits axon rege...
KEY FINDING: Wnt signaling, particularly the Wnt-Ryk pathway, inhibits axon regeneration after spinal cord injury, causing corticospinal tract axon retraction.
Antioxidants, 2023 • January 7, 2023
Neurological disorders and injuries can impair nerve regeneration and functional recovery due to factors like inflammation and oxidative stress. Quercetin, a dietary flavonoid, possesses neuroprotecti...
KEY FINDING: Quercetin administration in SCI animal models reduced histopathological damage, inflammatory cytokine synthesis, and cellular oxidative stress.