Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 181-190 of 2,317 results
Scientific Reports, 2015 • March 16, 2015
This study investigated whether electroacupuncture (EA) treatment could enhance grafted TrkC-MSCs to differentiate into oligodendrocytes, remyelination and functional recovery in a rat model of demyel...
KEY FINDING: TrkC-MSCs combined with EA significantly increased the number of OPCs and oligodendrocyte-like cells differentiated from MSCs.
Neural Regeneration Research, 2015 • January 1, 2015
This study compares the efficacy of electroacupuncture at local meridian acupoints alone with acupuncture at Governor vessel and local meridian acupoints combined for treating peripheral nerve injury....
KEY FINDING: Acupuncture at Governor vessel and local meridian acupoints combined (GV/LM) showed better clinical response (80%) compared to acupuncture at local meridian acupoints alone (LM) (38.5%).
Clin Trans Med, 2016 • September 21, 2016
The study examines the role of physiotherapy in improving mobilization in patients with spinal cord injury (SCI) who are also undergoing human embryonic stem cell (hESC) therapy. The research indicate...
KEY FINDING: Patients with AIS score A showed improvement to score B (15%) and C (37.3%) after hESC therapy and physiotherapy.
Korean J Neurotrauma, 2016 • August 1, 2016
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, su...
KEY FINDING: Direct intramedullary injection to the injured spinal cord site in subacute phase is most effective.
J. Clin. Med., 2015 • December 29, 2014
Spinal cord injury (SCI) is a devastating trauma causing long-lasting disability. The use of cell transplantation as a therapeutic strategy for the treatment of SCI is promising, particularly since it...
KEY FINDING: iPSC-derived cells can be useful in the treatment of SCI through cell replacement and restoration of lost myelin and through trophic support, which results in the induction of neuroprotection and a reduction in cell loss.
Stem Cells International, 2015 • February 5, 2015
This review highlights the progress in cell therapy for spinal cord injury (SCI) treatment, focusing on various cell types like pluripotent stem cells, mesenchymal stromal cells (MSCs), and neural ste...
KEY FINDING: Cell transplantation can enhance neuronal regeneration after spinal cord injury by secreting paracrine factors, acting as a scaffold for axonal regrowth, and replacing lost neurons or neural progenitor cells.
Stem Cell Res, 2015 • September 1, 2015
The study quantitatively evaluated the effect of transplantation dose on the spatiotemporal dynamics of human neural stem cell engraftment in the injured central nervous system. The findings suggest t...
KEY FINDING: Transplant dose was inversely correlated with measures of donor cell proliferation at 2 weeks post-transplant (WPT) and dose-normalized engraftment at 16 WPT.
Neurobiol Dis, 2017 • February 1, 2017
This study investigates the role of RhoA in axon regeneration and neuronal death after spinal cord injury (SCI) using a lamprey model, which allows for unambiguous study of true axon regeneration. The...
KEY FINDING: Knockdown of RhoA in vivo by retrogradely-delivered morpholino antisense oligonucleotides (MOs) to the RS neurons significantly reduced retrograde apoptosis signaling in identified RS neurons post-SCI.
The Journal of Spinal Cord Medicine, 2016 • January 1, 2016
This study explored the neuroprotective effects of local profound hypothermia and its mechanism of action after experimental spinal cord injury in rats. The results suggest that local profound hypothe...
KEY FINDING: Regional hypothermia downregulated the expressions of RhoA, ROCK-II, NG2, Neurocan, Brevican, and Nogo-A after spinal cord injury.
Oncotarget, 2017 • November 25, 2016
This study investigated the effects of pulsed electromagnetic field (PEMF) therapy on neuropathic pain induced by chronic constriction injury (CCI) in rats, focusing on the expression of HCN1/HCN2 mRN...
KEY FINDING: CCI induced neural cell degeneration, while PEMF promoted nerve regeneration as documented by Nissl staining.