Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 191-200 of 2,317 results
Cell Death & Disease, 2021 • April 29, 2021
This study analyzed human umbilical-cord-derived MSCs from 32 donors and found donor-dependent variations in cell proliferation and immune modulatory functions, potentially explaining inconsistent cli...
KEY FINDING: Human umbilical cord-derived MSCs from 32 donors showed donor-dependent variations in proliferation and immune modulation capabilities.
Top Spinal Cord Inj Rehabil, 2015 • January 1, 2015
As a scientific community, we have accomplished many things regarding the pathophysiology and treatment of SCI. These are exciting times in the field with many disciplines coming together to help targ...
KEY FINDING: Early decompression surgical procedures after severe SCI have been examined in both preclinical and clinical studies. Evidence suggests that these early surgical interventions are safe and effective, and they are currently recommended as an early intervention for patients with acute severe SCI.
PLoS ONE, 2015 • September 14, 2015
This study examines the role of neurofilaments (NFs) in axon regeneration in lampreys after spinal cord injury (SCI) using antisense morpholino oligonucleotides (MOs) to manipulate NF expression. The ...
KEY FINDING: Inhibition of NF180 expression with antisense MOs significantly reduced axon regeneration at 4 and 9 weeks post-TX.
Neurosci Lett, 2017 • June 23, 2017
Spinal cord injury (SCI) is a debilitating condition with limited effective treatments to relieve neurological deficits, primarily due to the failure of long-distance regeneration of severed axons. Ap...
KEY FINDING: Axonal regeneration and sprouting can be enhanced by neutralizing myelin- and extracellular matrix-associated inhibitors.
PLoS ONE, 2015 • October 1, 2015
This study demonstrates the effectiveness of a combinatorial therapy (PNG+aFGF+ChABC) in improving lower urinary tract function in mice with complete spinal cord transection. The treatment led to redu...
KEY FINDING: The combination of PNG+aFGF+ChABC reduced bladder weight and improved bladder and external urethral sphincter histology.
Neuropsychopharmacology Reviews, 2014 • January 1, 2014
The central nervous system's limited regenerative capacity necessitates innovative strategies for tissue and functional repair. Biomaterials, particularly hydrogels, are being investigated as cell- an...
KEY FINDING: Biomaterial hydrogels can enhance cell survival and integration in the CNS by mimicking the extracellular matrix (ECM) and providing physical support.
Scientific Reports, 2021 • November 4, 2021
The study aimed to enhance the differentiation potential of hEnSCs into MN-like cells and axonal elongation using the signaling molecules sonic hedgehog (SHH) and retinoic acid (RA), and also by provi...
KEY FINDING: The collagen hydrogel containing EpoB microspheres significantly improved the differentiation of hEnSCs into motor neuron-like cells.
Neural Plasticity, 2015 • July 1, 2015
This clinical trial investigated the safety and efficacy of human neural stem/progenitor cell (hNSPC) transplantation in patients with traumatic cervical spinal cord injury (SCI). Nineteen patients re...
KEY FINDING: hNSPC transplantation was safe and well-tolerated; no serious adverse events like tumor formation or neurological deterioration were observed.
Basic and Clinical, 2015 • October 1, 2015
This case report presents the outcomes of combination therapy using intrathecal mesenchymal stem cells (MSCs) and subcutaneous granulocyte-colony stimulating factor (G-CSF) along with a rehabilitation...
KEY FINDING: The patient's ASIA Impairment Scale (AIS) improved from A to C, indicating neurological improvement.
Scientific Reports, 2017 • January 9, 2017
This study demonstrates the potential of aligned fibrin hydrogel (AFG) to promote spinal cord regeneration in canines with spinal cord injury (SCI). Tractography imaging revealed new nerve fibers grow...
KEY FINDING: Tractography revealed new fibers running across the spinal cord injury in three canines treated with AFG.