Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 201-210 of 2,317 results
Cells, 2022 • March 10, 2022
The study aimed to determine whether batch effects related to cell culture materials could influence BMSC gene expression, phenotype, and function, specifically examining the impact of hPL versus FBS ...
KEY FINDING: hPL significantly increased BMSC proliferation, created significantly different gene expression trajectories and distinct surface marker signatures, already after just one passage.
PNAS, 2017 • January 13, 2017
The study developed a platform technology using hMSCs and a PLGA matrix to improve donor cell survival and localized engraftment in vivo. The synthetic matrix supports hMSC survival, stemness, and fun...
KEY FINDING: PLGA scaffolding augments hMSC stemness, engraftment, and function without neural transdifferentiation or mesenchymal lineage development.
Neural Regeneration Research, 2015 • December 1, 2015
This study investigated the effects of electroacupuncture on spinal cord injury (SCI) recovery in rats, focusing on motor neuron function. The findings indicate that electroacupuncture increases acety...
KEY FINDING: Electroacupuncture increased AChE activity at the injury site in the spinal cord. This suggests improved nerve function and communication.
Restorative Neurology and Neuroscience, 2016 • January 1, 2016
This study examined the effect of choroid plexus epithelial cell (CPEC) transplantation on locomotor improvement and tissue repair in rats with spinal cord injury (SCI). The results showed that CPEC t...
KEY FINDING: Transplantation of CPECs significantly improved locomotor behaviors in rats with SCI, as measured by BBB scores.
Neurol Med Chir (Tokyo), 2016 • April 6, 2016
This pilot study investigated the feasibility and safety of olfactory mucosa autograft (OMA) for treating chronic complete spinal cord injury. The procedure involves transplanting the patient's own ol...
KEY FINDING: The olfactory mucosa autograft (OMA) procedure was found to be safe, with no serious adverse events reported in any of the eight patients.
Stem Cells International, 2016 • January 10, 2016
The study aimed to assess the effect of L. angustifolia extract on the outcome of transplantation of HUMSCs from Wharton’s jelly after contusive SCI in Wistar rats. Behavioral tests showed that HUMSC ...
KEY FINDING: HUMSC transplantation alone improved locomotor function compared to the SCI control group.
The Journal of Neuroscience, 2015 • July 1, 2015
This study demonstrates that Pten deletion in postinjured adult corticospinal neurons enables a regenerative response in the mammalian spinal cord. Both the compensatory sprouting of intact CST axons ...
KEY FINDING: Pten deletion in adult mice promotes CST sprouting after unilateral pyramidotomy, as demonstrated by BDA tracing.
Advanced Biomedical Research, 2016 • January 1, 2016
This study investigated the safety and efficacy of co-infusing autologous adipose tissue-derived mesenchymal stem cells (N-Ad-MSC) and hematopoietic stem cells (HSCs) in patients with post-traumatic p...
KEY FINDING: The co-infusion of N-Ad-MSC and HSC in CSF is a safe and viable therapeutic approach for SCIs.
Bioactive Materials, 2023 • January 1, 2023
This study synthesized layered double hydroxide (LDH) nanoparticles and optimized their ion elemental compositions to promote chondrogenic differentiation of human umbilical cord mesenchymal stem cell...
KEY FINDING: LDH nanoparticles with specific ion compositions (MgFe–NO3) effectively promoted chondrogenic differentiation of hUC-MSCs.
Frontiers in Cell and Developmental Biology, 2017 • January 19, 2017
This review discusses the potential of induced pluripotent stem cells (iPSCs) for treating traumatic spinal cord injury (SCI). Cell-based therapies offer an exciting strategy to address this pressing ...
KEY FINDING: iPSCs can differentiate into neural precursor cells, neural crest cells, neurons, oligodendrocytes, astrocytes, and even mesenchymal stromal cells, offering diverse therapeutic potential for SCI.