Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 211-220 of 2,317 results
Journal of Craniovertebral Junction and Spine, 2016 • January 1, 2016
Stem cell therapy is being investigated as a potential treatment for spinal cord injury (SCI), which currently lacks effective primary treatment options. Various types of stem cells, including mesench...
KEY FINDING: Mesenchymal stem cells (MSCs), particularly bone marrow stromal cells (BMSCs), have shown improved functional recovery in rodent models of SCI and some clinical trials.
PLoS Biology, 2016 • May 31, 2016
This meta-analysis examined the efficacy of olfactory ensheathing cell (OEC) transplantation in experimental spinal cord injury (SCI). The study found a significant overall effect of OEC transplantati...
KEY FINDING: OEC transplantation improved locomotor recovery by 20.3% in experiments reporting BBB measures.
Cells, 2021 • November 27, 2021
Research over the last 20 years has explored using pluripotent stem cell (PSC)-derived cells to treat spinal cord injury (SCI) in various animal models. While these studies have increased our understa...
KEY FINDING: ESC-derived cells have shown efficacy in acute SCI models in animals, suggesting potential for human therapies, but require further optimization and safety measures to address tumorigenic risks.
Stem Cell Reports, 2017 • February 14, 2017
This study evaluated the efficacy of human neural stem cells (HuCNS-SCs) in a mouse model of cervical spinal cord injury (SCI), comparing a research cell line (RCL) and a clinical cell line (CCL) inte...
KEY FINDING: The research cell line (HuCNS-SC RCL) showed some improvement in locomotor function when transplanted 9 days post-injury (DPI) in mice with cervical SCI.
Neural Regeneration Research, 2016 • July 1, 2016
Transplantation of somatic cells like BMSCs, BMNCs, and CPECs enhances axon regeneration and locomotor improvements, despite their short-term survival and lack of integration into the host spinal cord...
KEY FINDING: BMSCs, BMNCs, and CPECs enhance axon regeneration and locomotor function without long-term survival in the host spinal cord, suggesting the release of trophic factors.
Stem Cell Reports, 2017 • February 16, 2017
This study investigates the efficacy of neural stem cell (NSC) transplantation in aged mice with spinal cord injury (SCI). It addresses the increasing number of elderly patients with SCI and the limit...
KEY FINDING: Aged mice exhibited less functional recovery from SCI than young mice, with higher mortality rates and larger damaged areas in the spinal cord.
Spinal Cord Series and Cases, 2016 • January 7, 2016
This case report details the recovery of a patient with chronic, complete SCI following olfactory mucosal autograft (OMA) transplantation combined with intensive rehabilitation. The patient showed imp...
KEY FINDING: The patient exhibited voluntary electromyograph (EMG) activity and MEPs at 96 and 144 weeks after transplantation.
Neural Regeneration Research, 2017 • January 1, 2017
Regenerative medicine offers hope for functional recovery in acute-to-subacute SCI, but chronic SCI treatment remains challenging. Combined therapies, especially those including rehabilitation, are ga...
KEY FINDING: Treadmill training combined with neural stem/progenitor cell (NS/PC) transplantation promotes functional recovery in chronic SCI, showing both additive and synergistic effects.
Scientific Reports, 2017 • March 6, 2017
This study investigated the therapeutic effects of a NeuroRegen scaffold functionalized with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in a canine chronic spinal cord injury (SCI)...
KEY FINDING: Functionalized NeuroRegen scaffold implantation promoted both locomotor recovery and endogenous neurogenesis in the lesion area.
International Journal of Molecular Sciences, 2017 • February 27, 2017
This study investigated the effects of transplanting embryonic spinal cord-derived cells into injured peripheral nerves to prevent muscle atrophy. Both fetal cells (P0) and neural progenitor cells (P2...
KEY FINDING: Both fetal spinal cord cells (P0) and neural progenitor cells (P2) were able to survive in the injured peripheral nerve environment.