Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 221-230 of 2,317 results
Front. Mol. Neurosci., 2015 • June 16, 2015
Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosi...
KEY FINDING: CNS myelin contains myelin-associated inhibitors (MAIs) including Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp) that collapse axonal growth cones and inhibit growth.
Front. Mol. Neurosci., 2015 • June 18, 2015
It has become increasingly clear that there is no single pathway, protein, or drug that can promote robust axonal regeneration in the injured CNS, but our microarray analysis of the conditioning lesio...
KEY FINDING: ArgI activity was sufficient to mediate this response.
Neural Regeneration Research, 2015 • April 1, 2015
This study investigated the combined effects of propofol injection and bone marrow mesenchymal stem cell (BMSC) transplantation on spinal cord injury (SCI) in rats. The research demonstrated that the ...
KEY FINDING: The combination therapy significantly reduced the cavity size within the spinal cord compared to monotherapy or the control group.
Molecular & Cellular Proteomics, 2015 • July 16, 2015
This study characterized the secretome of USSC derived from hUCB, identifying 1156 proteins, including 31 known neurite growth promoting factors. Functional validation confirmed that SPARC and PEDF, s...
KEY FINDING: USSC secretome contains 1156 proteins, including 31 well-known neurite growth promoting factors.
Stem Cells International, 2017 • February 16, 2017
This review discusses restorative approaches for spinal cord injuries (SCIs) using cell therapies, specifically olfactory ensheathing cells (OECs) and mesenchymal stem cells (MSCs). These cells have s...
KEY FINDING: Olfactory ensheathing cells (OECs) express neurotrophic factors that are important for axon extension and guidance. They can migrate from the peripheral to the central nervous system, enhancing axonal extension after injury.
Front. Mol. Neurosci., 2019 • April 12, 2019
This review discusses the potential of bioscaffolds and extracellular vesicles (EVs) in treating spinal cord injury (SCI). Bioscaffolds can bridge lesion gaps and facilitate axonal regeneration, while...
KEY FINDING: Bioscaffolds can ameliorate the spinal cord microenvironment and direct cell behaviors such as migration, proliferation and differentiation.
The Journal of Neuroscience, 2017 • September 20, 2017
This study demonstrates that the timing of hCNS-SCns transplantation post-SCI affects the localization and differentiation of donor cells. Acute transplantation (0 dpi) resulted in astroglial differen...
KEY FINDING: Acute transplantation of hCNS-SCns resulted in localized astroglial differentiation of donor cells near the lesion epicenter and failure to produce functional improvement.
Neural Regeneration Research, 2015 • June 1, 2015
This study investigated the effects of hydrogen-rich saline on spinal cord injury (SCI) in rats. Hydrogen-rich saline was administered into the subarachnoid space of rats after SCI. The results showed...
KEY FINDING: Hydrogen-rich saline markedly reduced cell death in the injured spinal cord tissue compared to the control group receiving physiological saline.
PLoS ONE, 2015 • July 29, 2015
The study modified an in vitro scarring model to study mechanisms of scar formation and reduction, and to investigate new scar-reducing treatments. The model uses a co-culture system of cerebral astr...
KEY FINDING: DFO treatment led to a significant reduction of scarring and slightly increased regeneration of corticospinal tract as well as ascending CGRP-positive axons.
Regenerative Therapy, 2024 • July 1, 2024
This review explores the potential of adipose-derived stem cell (ADSC) therapy for spinal cord injury (SCI), focusing on its ability to improve function, progress in preclinical and early clinical tri...
KEY FINDING: Preclinical studies suggest ADSC transplantation promotes functional recovery, reduces cavity formation, and enhances nerve regrowth and myelin repair in SCI models.