Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,191-2,200 of 2,317 results
Molecular Therapy, 2019 • December 1, 2019
This study investigates the role of UTX, a histone demethylase, in vascular regeneration following spinal cord injury (SCI). The researchers found that UTX expression increases in endothelial cells po...
KEY FINDING: UTX expression increases in endothelial cells following spinal cord injury in mice.
Neural Development, 2014 • May 22, 2014
This study investigates the transcriptome-wide response to spinal cord injury in regenerative (R-) and non-regenerative (NR-) stages of Xenopus laevis to identify mechanisms underlying successful rege...
KEY FINDING: Regenerative tadpoles showed extensive transcriptome changes at 1 day after injury, while non-regenerative froglets showed changes at 6 days after injury, indicating different kinetics in the responses.
Stem Cell Research & Therapy, 2021 • May 27, 2021
This study investigates the role of CD157 in BMSC-mediated mitochondrial transfer to improve neuronal apoptosis and functional recovery after spinal cord injury (SCI). The results suggest that CD157 c...
KEY FINDING: CD157 expression on BMSCs is upregulated when co-cultured with injured VSC4.1 motor neurons.
Neural Plasticity, 2015 • July 2, 2015
This study investigated the potential of combining Schwann cell (SC) transplantation with putrescine supplementation to improve spinal cord injury (SCI) repair in rats. The researchers hypothesized th...
KEY FINDING: Delayed putrescine supplementation significantly increased the size of the SC implant, suggesting enhanced survival or proliferation of the implanted cells.
Cellular & Molecular Biology Letters, 2022 • March 14, 2022
The study investigates the therapeutic potential of IL10-modified MSCs in a mouse model of SCI. IL10-MSCs were generated and assessed for safety and efficacy, showing improved motor function recovery ...
KEY FINDING: IL10-MSC treatment markedly reinforced locomotor improvement, accompanied with decreased lesion volume, regeneration of axons, and preservation of neurons, compared with naïve unmodified MSCs.
Cell Tissue Res, 2018 • January 1, 2018
Neural stem cells (NSCs) are the stem cells of the nervous system. During development they give rise to the entire nervous system. Because NSCs are regulated by both intrinsic genetic and epigenetic p...
KEY FINDING: During development, the central nervous system (CNS) is generated from a small number of neural stem cells (NSCs) lining the neural tube.
Skeletal Muscle, 2024 • May 13, 2024
The study investigates the impact of mouse strain, sex, and injury type on intramuscular fat (IMAT) formation, myofiber regeneration, and fibrosis. Results show that C57BL/6J mice are resistant to IMA...
KEY FINDING: Bl6 mice are more resistant to IMAT formation compared to 129S and CD1 strains.
Pharmaceuticals, 2019 • April 29, 2019
This review summarizes the potential of neural stem cells (NSCs) as a therapeutic approach for spinal cord injury (SCI), highlighting their regenerative properties and ability to restore damaged neuro...
KEY FINDING: NSCs have shown regenerative effects in SCI models by providing neurotrophic support and restoring synaptic connectivity.
Regeneration, 2015 • January 20, 2015
The study demonstrates targeted modification of the thrombospondin-1 (tsp-1) locus using transcription-activator-like effector nucleases (TALENs) in axolotls. It identifies a role of tsp-1 in recruitm...
KEY FINDING: TALENs can be effectively used to edit genes in axolotls, demonstrating a protocol for generating and genotyping mosaic axolotls with TALEN-mediated gene edits.
Stem Cell Reports, 2023 • May 9, 2023
The study investigates the behavior of transplanted human retinal organoid cells in photoreceptor-deficient mice. It examines how the recipient retina affects the survival, maturation, and proliferati...
KEY FINDING: Human cells transplanted into mice retinas migrated into all retinal layers, identified as astrocytes and brain/spinal cord-like neural precursors.