Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,201-2,210 of 2,317 results
Proc. Nad. Acad. Sci. USA, 1986 • October 1, 1986
The study examines the impact of forelimb amputation and denervation on protein synthesis in newt spinal cord ganglia, revealing a significant increase in protein synthesis following amputation. Two-d...
KEY FINDING: Forelimb amputation in newts leads to a fourfold increase in protein synthesis in the brachial nerve ganglia compared to control animals.
Brain, 2022 • January 4, 2022
The study demonstrates that Celsr2, highly expressed in spinal motor neurons, inhibits axon regeneration. Inactivating Celsr2 in mice and human motor neurons promotes axon growth, fasciculation, and f...
KEY FINDING: Celsr2 knockout promotes axon regeneration and fasciculation in mouse cultured spinal explants and cultured Celsr2 mutant motor neurons extend longer neurites and larger growth cones.
Neurotherapeutics, 2021 • April 15, 2021
The study investigates the potential of a novel antisense oligonucleotide (NVP-13) to recondition the neurogenic niche in adult non-human primates by attenuating TGFβ signaling. NVP-13 effectively dow...
KEY FINDING: NVP-13 significantly downregulated TGFβ-RII mRNA and protein expression in vitro in human neural precursor cells.
BMC Neurology, 2009 • July 15, 2009
This study investigates the expression patterns of CSPG family members (NG2, neurocan, versican, and phosphacan) in post-mortem human spinal cord samples after traumatic SCI to understand their role i...
KEY FINDING: NG2 and phosphacan were both detected in the evolving astroglial scar after human SCI, suggesting they might hinder CNS regeneration.
PLoS ONE, 2015 • September 22, 2015
This study demonstrates that high-dose ChABC treatment in the sub-acute stage of SCI effectively improves glial scar digestion by reducing the lesion size and increasing axonal regrowth to the related...
KEY FINDING: Intraparenchymal injection of high-dose ChABC in sub-acute SCI does not induce subarachnoid hemorrhage.
Journal of Oral Biology and Craniofacial Research, 2017 • February 4, 2017
Stem cells possess self-renewal and differentiation capabilities, holding potential for treating various conditions, including tooth loss. Dental stem cells, easily accessible, offer promise in treati...
KEY FINDING: Dental stem cells are found in primary and permanent teeth, including wisdom teeth, making them a readily available resource.
Scientific Reports, 2019 • May 7, 2019
This study investigates the role of epigenetic mechanisms, specifically histone deacetylases (HDACs), in axolotl tail regeneration using a chemical genetic screen. The screen identified several HDAC i...
KEY FINDING: A chemical screen identified 55 chemicals that inhibited axolotl tail regeneration, with histone deacetylase inhibitors (HDACi) being highly represented.
BioMed Research International, 2017 • November 19, 2017
This study investigates the apoptotic process in lamprey descending neurons after spinal cord injury (SCI), focusing on caspase activation and the involvement of the intrinsic apoptotic pathway. The r...
KEY FINDING: A significant correlation was found between the level of activated caspases (cell death markers) in identifiable neurons and their known regenerative ability after spinal cord injury in lampreys.
Neural Regeneration Research, 2016 • January 1, 2016
Spinal cord injury includes a primary mechanical injury and a much more complex secondary injury process involving inflammation, oxidation, excitotoxicity, and cell death. Among them, the RhoA/Rho kin...
KEY FINDING: Following SCI, active RhoA increases dramatically and remains elevated for an extended period in neurons, oligodendrocytes, and reactive astrocytes around the lesion area.
Scientific Reports, 2017 • September 22, 2017
We found that pre-treatment of DPCs with FGF2 significantly increased locomotor function recovery in SCI rats in response to DPC transplantation. The FGF2 priming protected DPCs from H2O2-induced cell...
KEY FINDING: Transplantation of DPC-FS markedly ameliorated SCI-induced hindlimb paralysis.