Regenerative Medicine & Stem Cells Research

KEY FINDING: SCOs effectively model spinal cord morphogenesis, offering insights into the intricate processes of neural tube formation and regional specification.

KEY FINDING: Highly porous, anisotropic silk scaffolds were successfully produced and demonstrated good cytocompatibility in vitro.

KEY FINDING: Gene therapy has gained promising advancement in the past decade, as six therapies have gained clinical approval for conditions such as spinal muscular atrophy or Leber’s congenital amaurosis.

KEY FINDING: Axolotl embryos can completely regenerate amputated tails in 7 days without feeding, making them an efficient model for regeneration studies.

KEY FINDING: Brain injury or tacrolimus alone, or their combination, alleviated muscle atrophy and nerve fiber impairment while improving sciatic nerve function.

KEY FINDING: Nestin expression is prominent in the rostral part of the spinal cord next to the lesion site one week after transection, implying neuronal progenitor migration to replace the missing tissue.

KEY FINDING: The AAVS1 locus in human cells is suitable for integrating conditional reporters for reliable transgene expression during lineage tracing.

KEY FINDING: mTOR signaling is the intrinsic axon regenerative pathway, and its reactivation can promote axon regeneration after adult CNS injury.

KEY FINDING: Netrin-1 acts as a chemorepellent for developing DRG axons, preventing them from projecting aberrantly toward the ventral spinal cord and ensuring correct projection toward the DREZ.

KEY FINDING: Mouse HAP stem cells can efficiently differentiate into dopaminergic neurons when cultured in neural-induction medium.