Regenerative Medicine & Stem Cells Research

KEY FINDING: Chronic stress impairs sensory axon regeneration in a preconditioning lesions mouse model.

KEY FINDING: Human spinal GABA neurons survived long-term and fully matured in the rat spinal cord after transplantation, differentiating into neurons and astrocytes.

KEY FINDING: MSC-EVs, including exosomes, alone or in combination with scaffolds can can regenerate the injured nerve in SCI.

KEY FINDING: NPC transplants are a potential pro-regenerative therapy that elicits a robust host axonal regeneration and extensive axonal extension from transplant-derived neurons.

KEY FINDING: The combination of RhoA MO plus ChABC had the best protective effect on identified reticulospinal (RS) neurons compared to control, ChABC alone, or RhoA MO alone at 4 weeks post-transection.

KEY FINDING: Neuro-PEG treatment led to the recovery of motor function in pigs after complete spinal cord transection.

KEY FINDING: Regenerative rehabilitation therapies are needed to circumvent the limitations of current treatment options and promote neurite regeneration and functional recovery following SCI, especially in the chronic phase.

KEY FINDING: The combined therapy significantly improved host-derived neuronal and oligodendrocyte differentiation at the SCI epicenter.

KEY FINDING: Transplanted NPCs secrete neurotrophic factors to attenuate secondary damage and differentiate into neurons that establish synaptic connections with host axons, contributing to functional recovery after SCI.

KEY FINDING: SRF expression increases after spinal cord injury (SCI) and promotes axonal regeneration.