Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 41-50 of 2,317 results
Frontiers in Molecular Neuroscience, 2024 • February 1, 2024
This study investigates the therapeutic potential of menstrual blood-derived stem cells (MenSCs) in treating spinal cord injury (SCI) in rats by analyzing transcriptome profiles. The research identifi...
KEY FINDING: MenSCs treatment improves motor function recovery and reduces spinal cord lesion volume in SCI rats.
Nature Communications, 2024 • March 6, 2024
This Phase I clinical trial demonstrates the safety of intrathecal administration of culture-expanded 1 × 108 cells of autologous AD-MSCs for patients with traumatic SCI. Stem cells were successfully ...
KEY FINDING: The study demonstrated that AD-MSC harvesting and administration were well-tolerated in patients with traumatic SCI.
Frontiers in Neurology, 2024 • April 2, 2024
This study investigates global research trends and hotspots in AI applications for spinal cord neural injury and restoration using bibliometric and visualization analysis. Key findings highlight the U...
KEY FINDING: The United States leads in the number of published articles on AI research in spinal cord neural injury and restoration.
Nature Communications, 2024 • April 1, 2024
This article is an author's correction to a previously published study on intrathecal delivery of adipose-derived mesenchymal stem cells (AD-MSCs) in traumatic spinal cord injury. The correction invol...
KEY FINDING: The average duration between injury and AD-MSC injection was corrected to 12 months (range of 7–22).
Frontiers in Cellular Neuroscience, 2024 • May 22, 2024
This study compared the effects of BMP4 alone and a bFGF/BMP4 combination on neural stem cells (NSCs) in vitro, using RNA sequencing to analyze transcriptome profiles and immunofluorescence to validat...
KEY FINDING: Both BMP4 alone and bFGF/BMP4 combination induce a quiescent state in neural stem cells (qNSCs), but they result in different levels of quiescence.
Cell Transplantation, 2024 • June 1, 2024
This study aimed to determine the optimal MSCs transplantation strategy for treating SCI by conducting a network meta-analysis of animal studies. The analysis of 32 animal studies revealed that MSCs i...
KEY FINDING: MSCs transplantation improves motor ability after SCI in animal models compared to controls.
Arch Bone Jt Surg, 2024 • June 1, 2024
Spinal cord injury (SCI) is a complex and incurable condition causing significant damage. While advancements in managing SCI have improved, a complete treatment for humans remains elusive due to the i...
KEY FINDING: The pathophysiology of SCI consists of a two-phase process: the primary mechanical injury and the subsequent cascade of auto-destructive damages. This cascade leads to inflammation, hemorrhage, demyelination, axon disruption, apoptosis, and necrosis.
Neurospine, 2024 • June 1, 2024
This study demonstrates that MSC-Exo treatment can effectively inhibit ferroptosis in BV2 cells and promote neurological recovery in SCI rats. The Nrf2/GCH1/BH4 signaling pathway plays a crucial role ...
KEY FINDING: MSC-Exo effectively inhibited the production of ferrous iron, lipid peroxidation products, and ferroptosis-promoting factor prostaglandin-endoperoxide synthase 2.
CNS Neurosci Ther, 2024 • June 18, 2024
This study aimed to confirm the inhibitory effect of nicotinamide on fibrotic scar formation following spinal cord injury (SCI) in mice using functional metabolomics. The researchers employed a novel ...
KEY FINDING: Nicotinamide (NAM) administration led to a reduction in fibrotic lesion area following spinal cord injury in mice.
Cells, 2024 • July 8, 2024
The study demonstrates that transplanting Schwann cells overexpressing GDNF into a completely transected spinal cord promotes the regeneration of propriospinal axons. GDNF improves the integration of ...
KEY FINDING: GDNF significantly improved graft-host integration by promoting the migration of reactive astrocytes into the Schwann cell territory.