Regenerative Medicine & Stem Cells Research

KEY FINDING: Both cBMMSC and sc-cBMMSC transplantation substantially improved rod-rotating time in cuprizone-induced demyelination mice, with a more significant effect observed in the sc-cBMMSC group.

KEY FINDING: Motor function, as measured by the BBB score, improved significantly more in the swimming group compared to the sedentary group at 3 and 6 weeks after SCI.

KEY FINDING: iNSCs demonstrate potential for direct neural regeneration and integration with host spinal cord tissue, offering advantages over other cellular therapies.

KEY FINDING: iPSCs can be differentiated into various cell types that play crucial roles in SCI treatment, including neural progenitor cells, oligodendrocyte progenitor cells, astrocytes, and microglia.

KEY FINDING: The PRP injection, combined with exercise, led to significant decreases in shoulder pain, as measured by the WUSPI, NRS, and physical exam scores, 24 weeks after treatment.

KEY FINDING: Neurons are responsible for transmitting information throughout the body, and their repair is critical for restoring voluntary movement below the injury site in SCI patients.

KEY FINDING: The study demonstrated that transplanting autologous human Schwann cells into chronic spinal cord injuries is feasible and appears to be safe.

KEY FINDING: Electroacupuncture enhances the production of endogenous NT-3 in damaged spinal cord tissues.

KEY FINDING: There were no significant adverse events throughout the study period.

KEY FINDING: rTSMS has a beneficial effect on modulating spinal scar tissue by reducing fibrosis, demyelination, and microglial cell activation, while increasing the astroglial component of the scar.