Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 51-60 of 2,317 results
Biological Research, 2024 • August 5, 2024
The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord after spinal cord injury can reprogram astrocytes into neurons and significantly enhance cell regeneration at the injury site. The rep...
KEY FINDING: Overexpression of NeuroD1 and Ngn2 in astrocytes promotes cell regeneration at the injury site after spinal cord injury.
Scientific Reports, 2024 • August 2, 2024
This study investigated the effects of repetitive magnetic stimulation (rMS) on neuronal death and nerve regeneration following peripheral nerve injury (PNI) in rats. The results indicated that rMS ca...
KEY FINDING: rMS prevents the decrease in DRG neurons post-injury, showing significantly higher DRG neuron counts at 1- and 4-weeks post-injury compared to the control group.
Int. J. Mol. Sci., 2024 • August 21, 2024
This study aimed to assess the effectiveness of epidural electric stimulation in promoting motor recovery in rats with spinal cord injury, as well as to elucidate the neurophysiological mechanisms und...
KEY FINDING: Epidural electrical stimulation (eSCS) significantly improved motor function in rats with spinal cord injury, as measured by the BBB scale.
Advanced Healthcare Materials, 2024 • September 1, 2024
This study introduces a biohybrid nerve graft made of decellularized rat sciatic nerve and PEDOT, optimized for electrical conductivity, mechanical properties, and biocompatibility. The optimized bioh...
KEY FINDING: A biohybrid nerve with a 1:1 ratio of FeCl3 to EDOT, cycled twice (DNP1:1C2), exhibited superior conductivity, mechanical alignment, and biocompatibility.
Cureus, 2024 • September 5, 2024
This case series investigated the use of autologous platelet-rich fibrin (PRF) on chronic non-healing ulcers with various etiologies in a rehabilitation center. The results indicate that PRF is a safe...
KEY FINDING: PRF treatment led to a maximum healing rate of 3.84% per day based on the PUSH score.
International Journal of Surgery, 2024 • October 24, 2024
This study demonstrates the dose-dependent effects of low-energy ESWT on motor function recovery, tissue regeneration, anti-inflammatory responses, and mitochondrial function in a rat model of SCI. Th...
KEY FINDING: Low-energy ESWT had a dose-dependent effect, with three treatment sessions (ESWT3) showing superior outcomes compared to a single session.
J. Clin. Med., 2024 • October 11, 2024
This case series investigated the safety and potential benefits of intravenous infusions of autologous mesenchymal stem cells (MSCs) for patients with chronic spinal cord injury (SCI). Seven patients ...
KEY FINDING: The intravenous infusion of autologous MSCs expanded in auto-serum is a safe and feasible therapeutic approach for chronic SCI patients.
Scientific Reports, 2024 • October 8, 2024
This study explores a combined therapy for spinal cord injury (SCI) in mice, using human umbilical cord mesenchymal stem cells (hUCMSCs), neural stem cells (NSCs), and epidural electrical stimulation ...
KEY FINDING: The combined therapy of hUCMSCs/NSCs transplantation and EES significantly improved motor function recovery compared to either treatment alone in mice with spinal cord crush injuries.
J Cell Mol Med, 2024 • October 1, 2024
This study investigates the potential of cBMMSC combined with nanosilver hydrogel nerve conduits to repair spinal cord injuries in rats. The experimental group received cBMMSC-containing hydrogel, whi...
KEY FINDING: cBMMSC transplantation based on nanosilver hydrogel nerve conduit was effective in repairing spinal cord injury, promoting neuronal and axonal regeneration, and restoring neuromotor and electrophysiological functions.
Scientific Reports, 2024 • December 2, 2024
This study investigates the role of bone marrow mesenchymal stem cells (BMMSCs) and miR-202-3p in treating spinal cord injury (SCI) in rats. The research demonstrates that BMMSCs, mediated by miR-202-...
KEY FINDING: BMMSCs improve motor function recovery in SCI rats, as evidenced by increased BBB scores and improved footprint analysis.