Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 71-80 of 2,317 results
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • February 2, 2021
This study demonstrated that inhibiting STAT3 not only promoted NSC differentiation into neurons, but also inhibited their differentiation into astrocytes, potentially through mTOR activation. The tra...
KEY FINDING: Knocking down STAT3 expression in rat NSCs promoted their neuronal differentiation in vitro, and upregulated the activity of mTOR.
Journal of International Medical Research, 2021 • June 1, 2021
This study evaluated the effectiveness of combining peripheral nerve grafting and acidic fibroblast growth factor (aFGF) infusion in reducing spasticity after spinal cord injury (SCI) in monkeys. The ...
KEY FINDING: The combined therapy of peripheral nerve grafting and aFGF infusion substantially reduced spasticity in leg muscle tone, patella tendon reflex, and fanning of toes in monkeys with SCI.
Stem Cell Research & Therapy, 2021 • January 31, 2021
This study examined the effects of LINGO-1 on spinal cord-derived NSPC (sp-NSPC) differentiation, its mechanisms, and functional recovery in mice after cell transplantation. LINGO-1 shRNA promotes neu...
KEY FINDING: LINGO-1 shRNA increased neuronal differentiation of spinal cord-derived NSPCs while decreasing astrocyte differentiation.
Science Progress, 2021 • July 1, 2021
Spinal cord injury (SCI) disrupts the sensorimotor pathway, leading to autonomic function loss. Research indicates that SCI impacts brain structure and function, highlighting the brain's plasticity. S...
KEY FINDING: SCI causes neuronal death/atrophy in the brain, which might be attributed to a series of biochemical processes.
Neural Regen Res, 2022 • March 1, 2022
This study introduces a high-density flexible electrode array for precise epidural spinal cord stimulation (ESCS) in rats with spinal cord injury (SCI). The research identifies specific spinal cord re...
KEY FINDING: The study identified specific regions in the spinal cord (L1 and L2 vertebral levels) where stimulation effectively activated the vastus lateralis (VL) and medial gastrocnemius (MG) muscles, respectively.
Cells, 2021 • July 26, 2021
This review addresses the different aspects that the spinal cord plasticity can take on. Recent discoveries underline the underestimation of the plasticity of the spinal cord at cellular and molecular...
KEY FINDING: Axonal regrowth can occur even after complete SCI, challenging the classical view of the spinal cord as nonregenerative.
J Neurosurg Spine, 2021 • September 3, 2021
This study presents a CGMP-compliant method for manufacturing autologous Schwann cells (SCs) for clinical use in treating spinal cord injuries (SCIs), peripheral nerve injuries (PNIs), and other condi...
KEY FINDING: The study produced an average yield of 87.2 ± 89.2 million cells at passage 2 (P2) and 150.9 ± 129.9 million cells at passage 3 (P3) with high viability and purity.
Scientific Reports, 2021 • September 16, 2021
This study introduces a thermosensitive injectable gel loaded with Decorin for treating spinal cord injuries in rats. The gel facilitates sustained Decorin release, reduces cavitation, promotes ECM de...
KEY FINDING: The BC/FB gel formed within 1 minute at 37 °C and released Decorin in a sustained manner for up to 30 days in vitro.
Neural Regeneration Research, 2022 • September 17, 2021
This study aimed to evaluate the impact of time-to-enrollment in chronic SCI clinical trials by analyzing data from ClinicalTrials.gov and individual patient data from regenerative intervention trials...
KEY FINDING: The majority of chronic SCI trials in ClinicalTrials.gov do not restrict the maximum post-injury time for trial eligibility.
Cells, 2021 • October 6, 2021
This review discusses the multifaceted pathophysiology of SCI and the potential of stem cell therapy, advocating for precision medicine approaches. It categorizes stem cell therapies into supportive a...
KEY FINDING: SCI pathophysiology is multifaceted, necessitating treatments that address dynamic interactions between various cell types. Stem cells are suited for this purpose due to their ability to duplicate, differentiate, and secrete trophic factors.