Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 81-90 of 2,317 results
Neural Regeneration Research, 2022 • November 12, 2021
This study investigates the effect of oscillating field stimulation (OFS) on axonal regeneration, astrocyte proliferation, and astrocyte reorientation after spinal cord injury (SCI), as well as the re...
KEY FINDING: Continuous OFS for more than 6 weeks effectively promotes motor function recovery in rats with spinal cord injury.
npj Regenerative Medicine, 2021 • October 21, 2021
This review summarizes the current progress of rehabilitative strategies in stem cell therapy for spinal cord injury. Regenerative rehabilitation is attracting wide attention owing to its synergistic ...
KEY FINDING: Regenerative rehabilitation can be categorized into conditioning/reconditioning, functional training, and physical exercise, which are indispensable for enhancing functional recovery achieved using stem cell therapies.
Frontiers in Cellular Neuroscience, 2021 • November 17, 2021
This review summarizes the current literature relating to the composition, purity, and cell dose of OEC cultures used for transplant-mediated repair of SCI. OEC transplants are not very well character...
KEY FINDING: Successful transplant-mediated repair appeared to be possible using both low and high proportions of OECs in olfactory transplants.
International Journal of General Medicine, 2021 • December 13, 2021
This study investigated the therapeutic potential of UC-MSC transplantation for SCI, using DTI to assess microstructural changes in the spinal cord. The experimental group received UC-MSC transplantat...
KEY FINDING: Significant differences were observed in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values before and after treatment in the experimental group (P < 0.05).
Brain Communications, 2021 • November 13, 2021
Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Following dorsal column lesions in mice and optic nerve crushes in rats, elevated levels of extracellular histone ...
KEY FINDING: Elevated levels of histone H3 were detected in human CSF 24 h after spinal cord injury.
Frontiers in Bioengineering and Biotechnology, 2022 • January 4, 2022
This study investigates the potential of GDF11, delivered via a lentiviral vector, to promote nerve regeneration after sciatic nerve injury in rats. The findings demonstrate that GDF11 promotes axonal...
KEY FINDING: GDF11 promotes the axonal growth of DRG cells in vitro, suggesting a direct effect on nerve regeneration.
Neural Regeneration Research, 2022 • September 1, 2022
CSPGs inhibit axon regeneration after SCI by interacting with receptors like PTPσ, LAR, and NgRs, activating RhoA and inactivating Akt signaling pathways. ChABC treatment can remove CSPGs, reactivate ...
KEY FINDING: Digestion of CSPGs with ChABC reduces retrograde apoptotic signaling and enhances true axon regeneration in lampreys after spinal cord transection.
NEURAL REGENERATION RESEARCH, 2022 • February 8, 2022
This study demonstrates that repetitive magnetic stimulation of the spinal cord nerve root induces functional recovery following SCI in rats. NRMS improves the excitability of the sensorimotor pathway...
KEY FINDING: Nerve root magnetic stimulation (NRMS) treatment leads to improved recovery of locomotor function following spinal cord injury (SCI).
Neural Plasticity, 2022 • February 2, 2022
This study explores the effect of the P2Y2 receptor (P2Y2R) on neuronal regeneration and angiogenesis after spinal cord injury (SCI) in rats. SCI animal models were created, and the P2Y2R inhibitor wa...
KEY FINDING: The expression of P2Y2R increases after SCI in rats, suggesting its involvement in the injury response.
International Journal of Molecular Sciences, 2022 • January 23, 2022
This review explores the use of biomaterials for peripheral nerve injury (PNI) and spinal cord injury (SCI), highlighting their potential to promote axonal regeneration and nervous system repair by mi...
KEY FINDING: Biomaterials can be engineered to mimic the extracellular matrix of nerve tissue, providing a scaffold for axonal regeneration and facilitating the delivery of therapeutic agents to the injury site.