Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 91-100 of 2,317 results
CNS Neuroscience & Therapeutics, 2022 • January 30, 2022
This review summarizes research on using Governor Vessel electro-acupuncture (GV-EA) combined with adult stem cell transplantation to repair spinal cord injuries (SCI). GV-EA improves the microenviron...
KEY FINDING: GV-EA can stimulate nerve endings, causing them to release substances that promote the survival and differentiation of transplanted stem cells at the injury site.
Cells, 2022 • February 16, 2022
Stem cell therapies have shown promise in the acute-to-subacute phase of SCI, but are less effective in the chronic phase due to tissue remodeling. Regenerative rehabilitation, combining regenerative ...
KEY FINDING: Regenerative rehabilitation can directly influence transplanted cells, promoting differentiation into neurons and oligodendrocytes, and inducing plastic changes in the lumbar enlargement of the spinal cord.
Bone Research, 2022 • October 11, 2022
This study investigates the cellular origin of neurogenic heterotopic ossifications (NHOs), which frequently develop in muscles after spinal cord injuries (SCIs). Using lineage-tracing experiments in ...
KEY FINDING: NHOs developing after SCI in injured muscles in mice are not derived from muscle SCs. We also reveal that NHOs only develop in areas of the injured muscle where SCs fail to regenerate myofibers.
Advanced Science, 2022 • March 4, 2022
This systematic review supports the idea that medical gases can protect cells against common diseases by controlling oxidation, inflammation, and cell death. Carbon monoxide can help restore nerve func...
KEY FINDING: Medical gases like carbon monoxide (CO) and xenon (Xe) show promise in protecting tissues and improving function, particularly in the central nervous system (CNS), heart, retina, liver, kidneys, and lungs.
Frontiers in Neuroscience, 2022 • February 17, 2022
This review focuses on the potential of Schwann cell (SC) transplantation as a therapeutic strategy for spinal cord injury (SCI). SCs offer multiple benefits, including enhancement of axon regeneratio...
KEY FINDING: SCs enhance axon regeneration through secretion of neurotrophic factors (NGF, BDNF, CNTF, and NT-3) and expression of adhesion molecules (L1 and NCAM) and ECM components (laminin, fibronectin, and collagen).
Frontiers in Medical Technology, 2022 • February 22, 2022
This review explores the emerging field of neural stem cell therapy and the engineering of functionalized biomaterials to facilitate cell transplantation and promote regeneration of damaged spinal cor...
KEY FINDING: NSCs are multipotent cells that can self-renew and generate all the specialized neural cells within the spinal cord, that is, neurons, astrocytes and oligodendrocytes.
Frontiers in Molecular Neuroscience, 2022 • April 8, 2022
This study presents a detailed protocol for differentiating human pluripotent stem cells (hPSCs) into spinal dI4 GABAergic interneurons (INs), which are crucial for spinal cord function and potential ...
KEY FINDING: A reproducible protocol was devised to differentiate human pluripotent stem cells (hPSCs) from enriched spinal dI4 inhibitory GABAergic INs.
Neural Regen Res, 2022 • April 1, 2022
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system. Over the last few decades, a great deal of...
KEY FINDING: OPCs are the most abundant proliferative population in the adult CNS, representing 5–8% of all cells, and can be recognized by the expression of membrane markers such as NG2 and PDGF.
Neural Regeneration Research, 2022 • December 1, 2022
This study investigated the potential of sodium selenite (SS) to promote neurological function recovery after spinal cord injury (SCI) by inhibiting ferroptosis in a rat model. The results showed that...
KEY FINDING: Sodium selenite treatment decreased iron concentration and levels of the lipid peroxidation products malondialdehyde and 4-hydroxynonenal in a rat model of spinal cord injury.
Cureus, 2022 • April 28, 2022
This review summarizes recent clinical trials investigating stem cell therapies for spinal cord injury (SCI). It discusses the pathophysiology of SCI and mechanisms of action of different stem cells. ...
KEY FINDING: Mesenchymal stem cells (MSCs) have shown promise due to their anti-apoptotic, neurotrophic, neuroprotective, and immunomodulatory effects.